VP, U.S. Medical Affairs
Dyne Therapeutics
June 27, 2026
Remote friendly (Waltham, MA)
United States
Medical Affairs
Primary Responsibilities
- Deliver a highly effective U.S. medical launch enabling appropriate, evidence-based adoption.
- Establish a credible scientific presence with U.S. KOLs, payers, and patient communities.
- Build a scalable, high-performing Medical Affairs organization for multiple launches.
- Translate scientific/clinical data into strategies that drive access and lifecycle value.
- Establish first-launch foundational capabilities and ways of working.
Enterprise & Launch Leadership
- Own U.S. medical strategy, launch readiness, and execution; ensure multiple successful launches from a medical affairs perspective.
- Build and develop a leadership bench.
- Serve on cross-functional launch leadership to shape enterprise decisions and resolve complex tradeoffs.
- Ensure Medical Affairs capabilities, processes, governance, and resourcing support launch and early commercialization.
- Represent U.S. Medical Affairs scientific priorities at USLT and GMA LT.
U.S. Medical Affairs Strategy & Execution
- Define and execute U.S. Medical Affairs strategy aligned to global strategy and enterprise objectives.
- Oversee tactics including KOL strategy, advisory boards, congresses, medical education, payer engagement, and scientific exchange.
Organization Building & People Leadership
- Build, lead, and scale Field Medical and home-office functions to operate with speed, rigor, and scientific credibility.
- Set goals, decision rights, and performance expectations.
- Ensure training and learning programs.
External Engagement & Scientific Leadership
- Serve as senior U.S. medical spokesperson to external stakeholders.
- Ensure compliant, high-quality medical/scientific exchange and real-time competitive intelligence.
Evidence Generation & Lifecycle Management
- Oversee U.S.-focused evidence generation aligned to launch/lifecycle priorities.
- Oversee the medical component of lifecycle management from launch through early commercialization.
Medical Governance & Compliance
- Ensure medical integrity, compliance, and ethical conduct.
- Oversee medical review processes to ensure rigor and regulatory compliance.
- Establish scalable medical governance frameworks.
Education & Skills Requirements
- MD, PhD, PharmD, or other relevant terminal degree.
- Rare disease and preferably neuromuscular launch experience.
- Experience leading Medical Affairs teams in commercialization, including field leadership.
- 20+ years related experience including 10+ years Medical Affairs plus clinical development/operations knowledge.
- Intermediate–advanced Microsoft Suite/MS Project/SharePoint/Veeva (or similar).
- Strong interpersonal, written/verbal communication, executive presence.
- Travel up to 50% (U.S. region and internationally at times).
- Fluent English (required).
- Integrity, compliance/ethics, enterprise mindset, builder mentality, ability to operate in ambiguity, executive influence.
Pay Range
- $196,000 - $285,000 USD.
- Deliver a highly effective U.S. medical launch enabling appropriate, evidence-based adoption.
- Establish a credible scientific presence with U.S. KOLs, payers, and patient communities.
- Build a scalable, high-performing Medical Affairs organization for multiple launches.
- Translate scientific/clinical data into strategies that drive access and lifecycle value.
- Establish first-launch foundational capabilities and ways of working.
Enterprise & Launch Leadership
- Own U.S. medical strategy, launch readiness, and execution; ensure multiple successful launches from a medical affairs perspective.
- Build and develop a leadership bench.
- Serve on cross-functional launch leadership to shape enterprise decisions and resolve complex tradeoffs.
- Ensure Medical Affairs capabilities, processes, governance, and resourcing support launch and early commercialization.
- Represent U.S. Medical Affairs scientific priorities at USLT and GMA LT.
U.S. Medical Affairs Strategy & Execution
- Define and execute U.S. Medical Affairs strategy aligned to global strategy and enterprise objectives.
- Oversee tactics including KOL strategy, advisory boards, congresses, medical education, payer engagement, and scientific exchange.
Organization Building & People Leadership
- Build, lead, and scale Field Medical and home-office functions to operate with speed, rigor, and scientific credibility.
- Set goals, decision rights, and performance expectations.
- Ensure training and learning programs.
External Engagement & Scientific Leadership
- Serve as senior U.S. medical spokesperson to external stakeholders.
- Ensure compliant, high-quality medical/scientific exchange and real-time competitive intelligence.
Evidence Generation & Lifecycle Management
- Oversee U.S.-focused evidence generation aligned to launch/lifecycle priorities.
- Oversee the medical component of lifecycle management from launch through early commercialization.
Medical Governance & Compliance
- Ensure medical integrity, compliance, and ethical conduct.
- Oversee medical review processes to ensure rigor and regulatory compliance.
- Establish scalable medical governance frameworks.
Education & Skills Requirements
- MD, PhD, PharmD, or other relevant terminal degree.
- Rare disease and preferably neuromuscular launch experience.
- Experience leading Medical Affairs teams in commercialization, including field leadership.
- 20+ years related experience including 10+ years Medical Affairs plus clinical development/operations knowledge.
- Intermediate–advanced Microsoft Suite/MS Project/SharePoint/Veeva (or similar).
- Strong interpersonal, written/verbal communication, executive presence.
- Travel up to 50% (U.S. region and internationally at times).
- Fluent English (required).
- Integrity, compliance/ethics, enterprise mindset, builder mentality, ability to operate in ambiguity, executive influence.
Pay Range
- $196,000 - $285,000 USD.