Senior Scientist - Analytical and Biological Mass Spectrometry (ABMS)
Regeneron
5 hours ago
On-site
Tarrytown, NY
Operations
A Typical Day In The Role Might Look Like
- Design, execute, and clearly communicate analytical characterization for biotherapeutics (including AAV, monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities) to support drug development.
- Lead and execute characterization activities to evaluate/ elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with an emphasis on charge detection mass spectrometry (CDMS) and related native-MS approaches.
- Provide analytical support for cross-functional teams (formulation development, upstream/downstream process development, and manufacturing).
- Proactively advance LC-MS characterization by developing innovative techniques that address evolving needs and improve operational efficiency.
- Independently conduct sample preparation and LC-MS analyses per SOPs; document procedures and results in an electronic laboratory notebook (ELN).
- Author and review regulatory submission documents (IND, comparability, BLA) and contribute to manuscripts for peer-reviewed publications.
- Represent analytical development on project teams; provide subject matter expertise and communicate results at internal/external meetings.
This Role Might Be For You If You
- Thrive in a fast-paced, collaborative environment; deliver results with efficiency and ownership.
- Quickly learn new technologies, tackle complex problems, and have a passion for science.
- Are self-motivated and proactive, prioritizing effectively and driving work forward with minimal supervision.
To be considered, you must have
- BS (10+ years), MS (7+ years), or PhD (0-3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
- Strongly preferred: experience with charge detection mass spectrometry (CDMS).
- Plus: experience applying LC-MS to extended characterization of AAV and monoclonal antibodies for product/process development.
- Desired: extensive experience with advanced mass spectrometers (e.g., Q Exactive Plus, Q Exactive UHMR, Q-TOF), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec).
- Plus: experience with experimental design and data analysis (e.g., molecular modeling, graphing, statistical analysis).
Application instructions
- Apply now.
- Design, execute, and clearly communicate analytical characterization for biotherapeutics (including AAV, monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities) to support drug development.
- Lead and execute characterization activities to evaluate/ elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with an emphasis on charge detection mass spectrometry (CDMS) and related native-MS approaches.
- Provide analytical support for cross-functional teams (formulation development, upstream/downstream process development, and manufacturing).
- Proactively advance LC-MS characterization by developing innovative techniques that address evolving needs and improve operational efficiency.
- Independently conduct sample preparation and LC-MS analyses per SOPs; document procedures and results in an electronic laboratory notebook (ELN).
- Author and review regulatory submission documents (IND, comparability, BLA) and contribute to manuscripts for peer-reviewed publications.
- Represent analytical development on project teams; provide subject matter expertise and communicate results at internal/external meetings.
This Role Might Be For You If You
- Thrive in a fast-paced, collaborative environment; deliver results with efficiency and ownership.
- Quickly learn new technologies, tackle complex problems, and have a passion for science.
- Are self-motivated and proactive, prioritizing effectively and driving work forward with minimal supervision.
To be considered, you must have
- BS (10+ years), MS (7+ years), or PhD (0-3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
- Strongly preferred: experience with charge detection mass spectrometry (CDMS).
- Plus: experience applying LC-MS to extended characterization of AAV and monoclonal antibodies for product/process development.
- Desired: extensive experience with advanced mass spectrometers (e.g., Q Exactive Plus, Q Exactive UHMR, Q-TOF), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec).
- Plus: experience with experimental design and data analysis (e.g., molecular modeling, graphing, statistical analysis).
Application instructions
- Apply now.