Senior Medical Director, Rheumatology
Alumis
June 26, 2026
Remote friendly (South San Francisco, CA)
United States
$300,000 - $358,000 USD yearly
Medical Affairs
Senior Medical Director, Clinical Development
Responsibilities:
- Serve as the physician lead for LUMUS, a 388-patient Phase 2b trial evaluating ESK-001 multiple doses in adult patients with moderately to severely active, autoantibody-positive SLE.
- Provide leadership of in-stream data reviews and reconciliation efforts.
- Author clinical portions of key study documents, including Protocol Amendments and Regulatory Submissions.
- Oversee the LUMUS medical monitor.
- Participate in external scientific engagement, including peer-to-peer interactions with MDs.
- Represent the company’s interests in rheumatology and support corporate initiatives.
- Coach, manage, inspire, and support team members to achieve goals.
- Maintain integrity and standards for scientific inquiry in drug development.
Primary goals (opening months):
- Establish credibility with internal/external stakeholders and serve as a strategic partner.
- Provide hands-on leadership and partner with operations to help LUMUS thrive.
- Improve and maintain study data quality, including cross-referencing main efficacy endpoints.
Candidate requirements:
- MD (or ex-US equivalent) with board certification in Rheumatology.
- 5+ years clinical development experience; lupus clinical trial background desired.
- Proven leadership experience managing people.
- Ability to assess, understand, and communicate expanding medical/scientific information.
- Strategic, organizational, and executional skills for project planning across multiple activities.
- Organized, detail-oriented approach and ability to meet timelines in a fast-paced environment.
- Experience working in matrixed, cross-functional teams.
- Strong interpersonal, influencing, presentation, and communication skills.
- Ability to work autonomously.
- Willingness to travel to HQ in South San Francisco one week per month.
Benefits:
- Health insurance premiums paid at 90% for employee and 80% for dependents.
- Genentech Bus & Ferry Share program access.
- $100 monthly cell phone stipend.
- Unlimited PTO for Exempt employees.
- Free onsite gym and stocked kitchen.
Location/hybrid:
- South San Francisco, CA; onsite Tuesday–Thursday for local employees; remote allowed with requirement to be onsite once a month.
Responsibilities:
- Serve as the physician lead for LUMUS, a 388-patient Phase 2b trial evaluating ESK-001 multiple doses in adult patients with moderately to severely active, autoantibody-positive SLE.
- Provide leadership of in-stream data reviews and reconciliation efforts.
- Author clinical portions of key study documents, including Protocol Amendments and Regulatory Submissions.
- Oversee the LUMUS medical monitor.
- Participate in external scientific engagement, including peer-to-peer interactions with MDs.
- Represent the company’s interests in rheumatology and support corporate initiatives.
- Coach, manage, inspire, and support team members to achieve goals.
- Maintain integrity and standards for scientific inquiry in drug development.
Primary goals (opening months):
- Establish credibility with internal/external stakeholders and serve as a strategic partner.
- Provide hands-on leadership and partner with operations to help LUMUS thrive.
- Improve and maintain study data quality, including cross-referencing main efficacy endpoints.
Candidate requirements:
- MD (or ex-US equivalent) with board certification in Rheumatology.
- 5+ years clinical development experience; lupus clinical trial background desired.
- Proven leadership experience managing people.
- Ability to assess, understand, and communicate expanding medical/scientific information.
- Strategic, organizational, and executional skills for project planning across multiple activities.
- Organized, detail-oriented approach and ability to meet timelines in a fast-paced environment.
- Experience working in matrixed, cross-functional teams.
- Strong interpersonal, influencing, presentation, and communication skills.
- Ability to work autonomously.
- Willingness to travel to HQ in South San Francisco one week per month.
Benefits:
- Health insurance premiums paid at 90% for employee and 80% for dependents.
- Genentech Bus & Ferry Share program access.
- $100 monthly cell phone stipend.
- Unlimited PTO for Exempt employees.
- Free onsite gym and stocked kitchen.
Location/hybrid:
- South San Francisco, CA; onsite Tuesday–Thursday for local employees; remote allowed with requirement to be onsite once a month.