Scientist III, Bioconjugation (ADC) Process Development
Exelixis
5 hours ago
On-site
Alameda, CA
Operations
Essential Duties/Responsibilities:
- Design, execute, and interpret experiments to develop, optimize, and scale biologics with a focus on ADC bioconjugation and purification.
- Develop subject matter expertise in bioconjugation (ADC) process development and manufacturing in support of CMC activities.
- Collaborate with research to understand conjugation chemistries and transition bioconjugation processes from research to CMC development.
- Identify, evaluate, and implement technologies to improve process efficiency, control, and understanding.
- Apply DOE and advanced statistical techniques to design process development experiments.
- Author technical documents (reports, SOPs, experimental protocols, tech transfer documents, batch record/sampling plan reviews).
- Support MFG floor activities with scale-up, technical support, and troubleshooting at clinical/commercial sites.
- Work effectively with CDMOs (plus).
- Preferred: familiarity with analytical, formulation, and general CMC scope for biologics.
Supervisory Responsibilities:
- None (directing work only; no direct reports).
Education:
- Bachelor’s in chemistry/biochemistry/pharmaceutical sciences/chemical engineering or related field + 3+ years relevant industry experience; or
- Master’s in the same fields + 1+ year relevant industry experience; or
- Equivalent education/experience.
Experience (including preferred/plus):
- Preferred: designing and implementing experiments to evaluate bioconjugation processes (including ADCs).
- Hands-on experience with ADC chemistry, reaction processes, and purification (e.g., TFF, chromatography).
- Plus: technical transfer experience for biologics manufacturing (bioconjugations).
- Plus: development/manufacturing of mAbs, bispecifics and/or linker-toxins for ADCs; familiarity with analytical methods.
Knowledge/Skills/Abilities (including preferred/plus):
- Cross-functional collaboration with internal teams and external CDMOs/partners.
- Ability to multitask in a fast-paced environment.
- Self-motivated, accountable, inquisitive; strong interpersonal, presentation, and written communication skills.
- Creative problem solver with attention to detail; able to work independently and in local/global teams.
- Environment: primarily labs/office; exposures to hazardous materials and extreme cold; limited travel required.
Benefits (if explicitly stated):
- Base pay range: $89,500–$128,000 annually.
- Total Rewards: 401k with generous company contributions; group medical/dental/vision; life and disability insurance; flexible spending accounts; discretionary annual bonus (or sales incentive plan for field sales); company stock purchase; long-term incentives; 15 vacation days (year 1); 17 paid holidays (including winter shutdown in December); up to 10 sick days annually.
- Design, execute, and interpret experiments to develop, optimize, and scale biologics with a focus on ADC bioconjugation and purification.
- Develop subject matter expertise in bioconjugation (ADC) process development and manufacturing in support of CMC activities.
- Collaborate with research to understand conjugation chemistries and transition bioconjugation processes from research to CMC development.
- Identify, evaluate, and implement technologies to improve process efficiency, control, and understanding.
- Apply DOE and advanced statistical techniques to design process development experiments.
- Author technical documents (reports, SOPs, experimental protocols, tech transfer documents, batch record/sampling plan reviews).
- Support MFG floor activities with scale-up, technical support, and troubleshooting at clinical/commercial sites.
- Work effectively with CDMOs (plus).
- Preferred: familiarity with analytical, formulation, and general CMC scope for biologics.
Supervisory Responsibilities:
- None (directing work only; no direct reports).
Education:
- Bachelor’s in chemistry/biochemistry/pharmaceutical sciences/chemical engineering or related field + 3+ years relevant industry experience; or
- Master’s in the same fields + 1+ year relevant industry experience; or
- Equivalent education/experience.
Experience (including preferred/plus):
- Preferred: designing and implementing experiments to evaluate bioconjugation processes (including ADCs).
- Hands-on experience with ADC chemistry, reaction processes, and purification (e.g., TFF, chromatography).
- Plus: technical transfer experience for biologics manufacturing (bioconjugations).
- Plus: development/manufacturing of mAbs, bispecifics and/or linker-toxins for ADCs; familiarity with analytical methods.
Knowledge/Skills/Abilities (including preferred/plus):
- Cross-functional collaboration with internal teams and external CDMOs/partners.
- Ability to multitask in a fast-paced environment.
- Self-motivated, accountable, inquisitive; strong interpersonal, presentation, and written communication skills.
- Creative problem solver with attention to detail; able to work independently and in local/global teams.
- Environment: primarily labs/office; exposures to hazardous materials and extreme cold; limited travel required.
Benefits (if explicitly stated):
- Base pay range: $89,500–$128,000 annually.
- Total Rewards: 401k with generous company contributions; group medical/dental/vision; life and disability insurance; flexible spending accounts; discretionary annual bonus (or sales incentive plan for field sales); company stock purchase; long-term incentives; 15 vacation days (year 1); 17 paid holidays (including winter shutdown in December); up to 10 sick days annually.