Global Medical Director, Medical Affairs
Dyne Therapeutics
August 13, 2026
On-site
Waltham, MA
Medical Affairs
Role: Global Medical Director, Medical Affairs (Waltham, MA)
Primary Responsibilities:
- Serve as Global Medical Affairs representative and strategic medical lead on cross-functional teams for assigned neuromuscular disease programs.
- Develop and execute integrated global medical plans aligned to corporate, program, product, evidence generation, and launch readiness priorities.
- Act as medical/scientific subject matter expert on Dyne FORCE platform, oligonucleotide and related modalities, and the clinical/diagnostic/treatment landscape.
- Maintain deep knowledge of literature, clinical data, competitive intelligence, diagnostic pathways, patient journeys, and unmet needs.
- Lead/support KOL, payer, investigator, and external expert engagement strategies (landscape mapping, planning, insight gathering/synthesis/reporting).
- Partner with Clinical Development, Clinical Operations, Regulatory Affairs, Biometrics, Translational Medicine, and Program Leadership for trial planning, site engagement, data interpretation, and medical input.
- Identify medical evidence gaps; support evidence generation (real-world evidence, investigator-sponsored research, post hoc analyses, natural history, registries, etc.).
- Support publication strategy, congress/symposia, medical education, abstracts/posters/presentations, and other scientific communications.
- Partner with Value & Access, Commercial, New Product Planning, Patient Advocacy, and regional teams for TPP development, patient identification, patient journey mapping, payer engagement, and launch readiness.
- Support external engagements (advisory boards, expert panels, congresses, medical education) per policies and regulations.
- Provide compliant medical input to internal/external materials; support business development/partnered assets with medical perspective.
Education & Qualifications:
- Advanced scientific/clinical degree required; MD/PhD/PharmD or equivalent preferred.
- 10+ years relevant experience; 6+ years in industry in Medical Affairs/Clinical Development/Scientific Communications or related roles.
- Rare disease experience required; neuromuscular disease/genetic medicines/oligonucleotides/ASOs strongly preferred.
- Work well in matrixed organizations and lead cross-functional medical strategy/evidence/KOL/congress/publication/medical education efforts.
- Strong scientific acumen; ability to interpret and translate clinical/nonclinical/biomarker/real-world/competitive data.
- Proven stakeholder relationship-building skills (KOLs, HCPs, investigators, payers, patient advocacy).
- Excellent written/verbal/presentation skills; strong collaboration, influencing, prioritization, problem-solving.
- Working knowledge of medical affairs/compliance/regulatory/scientific exchange standards.
- Travel as needed; authorized to work in the U.S.
Pay Range (base): $215,000–$260,000 USD.
Primary Responsibilities:
- Serve as Global Medical Affairs representative and strategic medical lead on cross-functional teams for assigned neuromuscular disease programs.
- Develop and execute integrated global medical plans aligned to corporate, program, product, evidence generation, and launch readiness priorities.
- Act as medical/scientific subject matter expert on Dyne FORCE platform, oligonucleotide and related modalities, and the clinical/diagnostic/treatment landscape.
- Maintain deep knowledge of literature, clinical data, competitive intelligence, diagnostic pathways, patient journeys, and unmet needs.
- Lead/support KOL, payer, investigator, and external expert engagement strategies (landscape mapping, planning, insight gathering/synthesis/reporting).
- Partner with Clinical Development, Clinical Operations, Regulatory Affairs, Biometrics, Translational Medicine, and Program Leadership for trial planning, site engagement, data interpretation, and medical input.
- Identify medical evidence gaps; support evidence generation (real-world evidence, investigator-sponsored research, post hoc analyses, natural history, registries, etc.).
- Support publication strategy, congress/symposia, medical education, abstracts/posters/presentations, and other scientific communications.
- Partner with Value & Access, Commercial, New Product Planning, Patient Advocacy, and regional teams for TPP development, patient identification, patient journey mapping, payer engagement, and launch readiness.
- Support external engagements (advisory boards, expert panels, congresses, medical education) per policies and regulations.
- Provide compliant medical input to internal/external materials; support business development/partnered assets with medical perspective.
Education & Qualifications:
- Advanced scientific/clinical degree required; MD/PhD/PharmD or equivalent preferred.
- 10+ years relevant experience; 6+ years in industry in Medical Affairs/Clinical Development/Scientific Communications or related roles.
- Rare disease experience required; neuromuscular disease/genetic medicines/oligonucleotides/ASOs strongly preferred.
- Work well in matrixed organizations and lead cross-functional medical strategy/evidence/KOL/congress/publication/medical education efforts.
- Strong scientific acumen; ability to interpret and translate clinical/nonclinical/biomarker/real-world/competitive data.
- Proven stakeholder relationship-building skills (KOLs, HCPs, investigators, payers, patient advocacy).
- Excellent written/verbal/presentation skills; strong collaboration, influencing, prioritization, problem-solving.
- Working knowledge of medical affairs/compliance/regulatory/scientific exchange standards.
- Travel as needed; authorized to work in the U.S.
Pay Range (base): $215,000–$260,000 USD.