(Associate) Director, Clinical Science

Role: Associate Director, Clinical Science, leading scientific and clinical strategy for early-phase (Phase 1/2) Orexin receptor programs targeting neurodegeneration and neuropsychiatric indications. Responsibilities include designing and executing clinical trials, authoring key regulatory and scientific documents, and providing scientific leadership across cross-functional teams such as Clinical Development, Regulatory Affairs, and Biometrics. The role involves integrating biomarker and mechanistic data, interpreting safety and efficacy results, and supporting regulatory submissions and scientific communications. Requirements: PhD or PharmD with 8-10 years in clinical research or biotech/pharma, with strong neuroscience/neurology expertise and experience in early-phase clinical trials. Preferred experience in sleep/wake mechanisms or Orexin biology is advantageous. Skills in clinical trial design, data analysis, scientific interpretation, and document development are essential. The position is based in the US, with occasional travel. The role emphasizes leadership in neurodegenerative/neuropsychiatric drug development, with a focus on sleep-wake disorders, utilizing bioscience and clinical trial expertise to advance Centessa’s pipeline.