Advisor/Senior Advisor, Purification Development
Eli Lilly and Company
4 hours ago
On-site
Indianapolis, IN
Operations
Responsibilities:
- Identify and develop new purification technologies.
- Design optimized downstream drug substance processes for new biologic candidates.
- Maintain accurate records and interpret data to provide detailed information and analysis on the execution of experiments.
- Employ strategic thinking to overcome technical hurdles and oversee process and technical transfer to GMP manufacturing facilities (discovery to clinic).
- Write technical reports, tech transfer documents, and give presentations to summarize development activities.
- Maintain flexibility to accept new projects and challenges.
- Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability.
Basic Requirements:
- PhD in Chemical Engineering or related degree focused on biological separation sciences; OR
- MS in Chemistry, Chemical Engineering, or related degree with at least 5 years of relevant experience leading protein purification/process development; OR
- BS in Chemistry, Chemical Engineering, or related degree with at least 8 years of relevant experience leading protein purification/process development.
Additional Preferences:
- Attention to detail; quality-minded approach to experimental design and record keeping.
- Effective oral and written communication skills.
- Strong laboratory skills.
- Experience purifying complex bioconjugates (e.g., ADCs, PEGylated proteins, antibody–oligonucleotide conjugates).
- Purification development experience with AAV, mRNA, or other gene therapy strategies.
- Extensive knowledge of membrane filtration.
- Ability to interact and form dynamic relationships with a wide range of groups.
- Experience with process control and documentation systems (Unicorn, Empower, electronic laboratory notebooks).
- Interpersonal skills; mentoring, feedback, training.
- Basic analytical skills and understanding.
- Advanced problem-solving skills.
- Experience interfacing with CDMOs or external development partners.
- Experience supporting late-phase process development activities (e.g., risk assessment, process characterization, regulatory filing).
- Identify and develop new purification technologies.
- Design optimized downstream drug substance processes for new biologic candidates.
- Maintain accurate records and interpret data to provide detailed information and analysis on the execution of experiments.
- Employ strategic thinking to overcome technical hurdles and oversee process and technical transfer to GMP manufacturing facilities (discovery to clinic).
- Write technical reports, tech transfer documents, and give presentations to summarize development activities.
- Maintain flexibility to accept new projects and challenges.
- Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability.
Basic Requirements:
- PhD in Chemical Engineering or related degree focused on biological separation sciences; OR
- MS in Chemistry, Chemical Engineering, or related degree with at least 5 years of relevant experience leading protein purification/process development; OR
- BS in Chemistry, Chemical Engineering, or related degree with at least 8 years of relevant experience leading protein purification/process development.
Additional Preferences:
- Attention to detail; quality-minded approach to experimental design and record keeping.
- Effective oral and written communication skills.
- Strong laboratory skills.
- Experience purifying complex bioconjugates (e.g., ADCs, PEGylated proteins, antibody–oligonucleotide conjugates).
- Purification development experience with AAV, mRNA, or other gene therapy strategies.
- Extensive knowledge of membrane filtration.
- Ability to interact and form dynamic relationships with a wide range of groups.
- Experience with process control and documentation systems (Unicorn, Empower, electronic laboratory notebooks).
- Interpersonal skills; mentoring, feedback, training.
- Basic analytical skills and understanding.
- Advanced problem-solving skills.
- Experience interfacing with CDMOs or external development partners.
- Experience supporting late-phase process development activities (e.g., risk assessment, process characterization, regulatory filing).