Sr. Principal - Engineer - Automation (Small Molecule)
Eli Lilly and Company
August 29, 2026
On-site
Houston, TX
Operations
Responsibilities:
- Lead design and delivery of the Emerson DeltaV platform and associated software integration teams for manufacturing expansion.
- Lead one or more automation DCS project workstreams (design, scheduling, staffing, and qualification) for Drug Substance (API) network.
- Collaborate with A&E firms, system integrators, corporate/site engineering peers, and Tech@Lilly to develop and manage DeltaV DCS system/software (design, testing, startup, qualification).
- Support GMP manufacturing operations post-delivery for small molecule or oligonucleotides.
- Champion safety culture; mentor and coach others; apply engineering/automation fundamentals in design and problem solving.
Key Deliverables:
- Develop requirements/specifications for software development and system architecture.
- Manage system integrators to deliver and test DeltaV software.
- Collaborate with Tech@Lilly to deliver scaled Automation/MES solution.
- Participate in basic/detailed design (staffing, statements of work, supplier management, delivery strategies).
- Develop computer system validation strategies.
- Develop/build Houston site automation team capabilities.
- Develop automation platform procedures/administration activities.
- Provide engineering support for PSM and PHRs.
- Provide technical oversight for equipment/process User Requirements and Design Review/Qualification documentation.
Basic Qualifications:
- Bachelor’s degree in engineering or related discipline.
- 8+ years process automation experience with Emerson DeltaV platform.
Additional Skills/Preferences:
- 5+ years API/Drug Substance manufacturing preferred (related manufacturing considered).
- Process instrumentation knowledge; batch control; data historian utilization; system integration incl. MES.
- Strong analytical/critical thinking; collaboration and ability to influence.
Additional Information:
- Travel potential <20% (domestic and/or international).
- Lead design and delivery of the Emerson DeltaV platform and associated software integration teams for manufacturing expansion.
- Lead one or more automation DCS project workstreams (design, scheduling, staffing, and qualification) for Drug Substance (API) network.
- Collaborate with A&E firms, system integrators, corporate/site engineering peers, and Tech@Lilly to develop and manage DeltaV DCS system/software (design, testing, startup, qualification).
- Support GMP manufacturing operations post-delivery for small molecule or oligonucleotides.
- Champion safety culture; mentor and coach others; apply engineering/automation fundamentals in design and problem solving.
Key Deliverables:
- Develop requirements/specifications for software development and system architecture.
- Manage system integrators to deliver and test DeltaV software.
- Collaborate with Tech@Lilly to deliver scaled Automation/MES solution.
- Participate in basic/detailed design (staffing, statements of work, supplier management, delivery strategies).
- Develop computer system validation strategies.
- Develop/build Houston site automation team capabilities.
- Develop automation platform procedures/administration activities.
- Provide engineering support for PSM and PHRs.
- Provide technical oversight for equipment/process User Requirements and Design Review/Qualification documentation.
Basic Qualifications:
- Bachelor’s degree in engineering or related discipline.
- 8+ years process automation experience with Emerson DeltaV platform.
Additional Skills/Preferences:
- 5+ years API/Drug Substance manufacturing preferred (related manufacturing considered).
- Process instrumentation knowledge; batch control; data historian utilization; system integration incl. MES.
- Strong analytical/critical thinking; collaboration and ability to influence.
Additional Information:
- Travel potential <20% (domestic and/or international).