Sr. Director Evidence Generation

Role Summary

Senior Director, Evidence Generation, Skeletal Dysplasia is a senior medical leadership role within BridgeBio's Medical Affairs. The role is responsible for developing and executing the integrated evidence generation strategy across BridgeBio’s skeletal dysplasia programs. The role leads the design and implementation of real-world evidence (RWE), HEOR, Phase 4, registry, and investigator-sponsored research strategies to support clinical development, regulatory objectives, value demonstration, and lifecycle management. Reporting to the CMAO, Skeletal and Endocrinology, this position shapes the evidence strategy to support launch readiness and post-marketing commitments, while ensuring alignment across Clinical Development, Regulatory, Commercial, Market Access, and Field Medical. It requires deep expertise in rare disease evidence generation, scientific rigor, and cross-functional leadership in a matrixed organization. Location: remote or hybrid/on-site in San Francisco.

Responsibilities

• Lead the development and execution of the integrated evidence generation strategy for skeletal dysplasia programs, aligned with overarching medical and asset strategy
• Design and oversee real-world evidence (RWE) initiatives, including registries, natural history studies, external data collaborations, and database analyses
• Partner with HEOR to generate data supporting value demonstration, payer engagement, and health technology assessment (HTA) requirements
• Lead Phase 4 planning and execution, including post-marketing commitments and lifecycle management studies
• Develop and manage investigator-initiated study (IIS) strategy and governance to address key scientific gaps
• Partner with Clinical Development to ensure evidence generation plans are integrated across development phases and support regulatory interactions
• Collaborate with Regulatory, Commercial, Market Access, and Patient Advocacy to ensure evidence plans address stakeholder needs
• Establish and maintain relationships with key opinion leaders (KOLs), academic investigators, and patient organizations within skeletal dysplasia and related specialties
• Represent BridgeBio at scientific congresses, advisory boards, and external forums
• Oversee evidence dissemination strategy in partnership with Scientific Communications, including publications and congress presentations
• Serve as medical reviewer and approver for relevant medical and cross-functional materials to ensure scientific accuracy and compliance
• Contribute to internal medical education and onboarding initiatives

Qualifications

• Required: MD, DO, PharmD, PhD, or equivalent advanced scientific or clinical degree
• Required: 10+ years of experience in Medical Affairs, Clinical Development, HEOR, or Evidence Generation roles within the biopharmaceutical industry and/or academic medicine
• Preferred: Demonstrated experience leading integrated evidence generation strategy in rare disease strongly preferred
• Preferred: Experience in skeletal disorders, endocrinology, rare genetic diseases, or metabolic bone disease
• Required: Proven expertise in real-world evidence (RWE), registries, HEOR, and Phase 4 study design and execution
• Required: Experience supporting late-stage development, launch preparation, and post-marketing medical activities
• Required: Strong understanding of regulatory and compliance requirements related to medical research and post-marketing studies
• Required: Demonstrated ability to lead cross-functional teams in a matrixed, fast-paced environment
• Required: Strategic thinker with strong execution capabilities
• Required: Excellent written and verbal communication skills, including experience presenting to senior leadership and external stakeholders
• Required: High degree of scientific rigor, integrity, and patient-centered focus

Additional Requirements

• Travel: Ability to travel up to 30-40% domestically and internationally for scientific meetings, advisory boards, investigator meetings, and internal engagements; occasional evening and weekend work may be required based on business needs.