Small Scale Oligonucleotide Synthesis, Process Development Co-op (Spring 2026)
Wave Life Sciences
Full-time
On-site
Lexington, MA
Clinical Research and Development
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Role Summary
Small Scale Oligonucleotide Synthesis, Process Development Co-op (Spring 2026) at Wave Life Sciences – Lexington, MA. This role involves supporting oligonucleotide synthesis, formulation, purification, and analysis to meet Discovery-related requests in a fast-paced biotech environment. Ideal for students with strong organizational skills and attention to detail pursuing a science program.
Responsibilities
- Prepare reagents and amidites for oligonucleotide synthesis
- Learn about solid phase synthesis and operate a Mermade192X synthesizer
- Purify oligonucleotides by preparative HPLC
- Analyze oligonucleotides by LC-MS, UV and pH
- Learn additional instrumentation including lyophilizers, speed vacs, nanodrop and UPLC
- Gain exposure to the use of an automated liquid handler for high throughput plate-based sample preparation
- Record and present data in an electronic laboratory notebook (ELN)
Qualifications
- Currently enrolled in an undergraduate or graduate science program in Chemistry, Biology, Biotechnology or related field
- Coursework in organic chemistry is required; biochemistry and analytical chemistry is a plus
- Understanding of laboratory best practices and safety protocols
- Attention to detail and well organized
- Laboratory experience with common laboratory operations including pipetting, weighing, and centrifugation preferred
- Enthusiasm for DNA/RNA therapeutic development