Small Scale Oligonucleotide Synthesis, Process Development Co-op (Spring 2026)

Role Summary

Co-op, Small Scale Oligonucleotide Synthesis, Process Development at Wave Life Sciences in Lexington, MA. This role supports Discovery-related activities by fulfilling oligo requests and ensuring sample quality, within a team-oriented, fast-paced biotech environment. Ideal for students with an interest in oligonucleotide synthesis and strong organizational skills.

Responsibilities

• Prepare reagents and amidites for oligonucleotide synthesis
• Learn about solid phase synthesis and operate a Mermade192X synthesizer
• Purify oligonucleotides by preparative HPLC
• Analyze oligonucleotides by LC-MS, UV and pH
• Learn additional instrumentation including lyophilizers, speed vacs, nanodrop and UPLC
• Gain exposure to the use of an automated liquid handler for high throughput plate-based sample preparation
• Record and present data in an electronic laboratory notebook (ELN)

Qualifications

• Currently enrolled in an undergraduate or graduate science program in Chemistry, Biology, Biotechnology or related field
• Coursework in organic chemistry is required, biochemistry and analytical chemistry is a plus
• Understanding of laboratory best practices and safety protocols
• Attention to detail and well organized
• Laboratory experience with common laboratory operations including pipetting, weighing, and centrifugation preferred
• Enthusiasm for DNA/RNA therapeutic development