Senior Scientist - Small Molecule and Oligonucleotide Process Sciences
Intellia Therapeutics, Inc.
September 04, 2026
Remote friendly (Cambridge, MA)
United States
Operations
Responsibilities:
- Lead development, optimization, and characterization of solid-phase oligonucleotide synthesis (upstream focus), emphasizing scalability and tech transfer (OP100 scale)
- Design and execute process characterization studies/DoEs and troubleshoot analytical data
- Support downstream purification processes to improve yield, purity, and reproducibility
- Support MSAT with tech transfer, process validation, and continuous process verification as needed
- Track milestones, dependencies, and risks across concurrent PD workstreams
- Manage day-to-day lab resourcing and prioritization
- Coordinate with external manufacturing/supply chain and CDMOs in support of sgRNA and lipid manufacturing
- Author/review SOPs, batch records, development reports, regulatory filing sections, and process validation/change control documentation
- Represent Process Development with updates to cross-functional teams (technical and non-technical)
- Serve as process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor/train junior scientists and collaborate with stakeholders across modalities
Qualifications:
- Solid expertise in phosphoramidite and oligonucleotide process chemistry; hands-on experience with automated synthesizers (OP100, Oligosynt platforms) and HPLC
- Strong organic chemistry foundation; working knowledge of small molecule manufacturing processes (advantage)
- Proficiency in HPLC and LC-MS for oligonucleotide characterization and analytical troubleshooting
- Excellent technical writing skills; authored SOPs/reports/regulatory documents; highly organized and able to manage multiple workstreams
- PhD in Organic Chemistry, Biochemistry, Biotechnology, or related field
- MS or BS in a related scientific discipline
- PhD or MS in Chemistry/Organic Chemistry/Nucleoside Chemistry or related discipline with minimum 2 (PhD) or 8 (MS) years’ experience (preferably oligonucleotide field)
- Hands-on solid-phase oligonucleotide synthesis; familiarity with GxP, quality systems, and pharmaceutical development lifecycle
- Experience driving multiple workstreams with cross-functional and external partners
Application instructions:
- Applications are accepted on a rolling basis until the position is filled.
- Lead development, optimization, and characterization of solid-phase oligonucleotide synthesis (upstream focus), emphasizing scalability and tech transfer (OP100 scale)
- Design and execute process characterization studies/DoEs and troubleshoot analytical data
- Support downstream purification processes to improve yield, purity, and reproducibility
- Support MSAT with tech transfer, process validation, and continuous process verification as needed
- Track milestones, dependencies, and risks across concurrent PD workstreams
- Manage day-to-day lab resourcing and prioritization
- Coordinate with external manufacturing/supply chain and CDMOs in support of sgRNA and lipid manufacturing
- Author/review SOPs, batch records, development reports, regulatory filing sections, and process validation/change control documentation
- Represent Process Development with updates to cross-functional teams (technical and non-technical)
- Serve as process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor/train junior scientists and collaborate with stakeholders across modalities
Qualifications:
- Solid expertise in phosphoramidite and oligonucleotide process chemistry; hands-on experience with automated synthesizers (OP100, Oligosynt platforms) and HPLC
- Strong organic chemistry foundation; working knowledge of small molecule manufacturing processes (advantage)
- Proficiency in HPLC and LC-MS for oligonucleotide characterization and analytical troubleshooting
- Excellent technical writing skills; authored SOPs/reports/regulatory documents; highly organized and able to manage multiple workstreams
- PhD in Organic Chemistry, Biochemistry, Biotechnology, or related field
- MS or BS in a related scientific discipline
- PhD or MS in Chemistry/Organic Chemistry/Nucleoside Chemistry or related discipline with minimum 2 (PhD) or 8 (MS) years’ experience (preferably oligonucleotide field)
- Hands-on solid-phase oligonucleotide synthesis; familiarity with GxP, quality systems, and pharmaceutical development lifecycle
- Experience driving multiple workstreams with cross-functional and external partners
Application instructions:
- Applications are accepted on a rolling basis until the position is filled.