Senior Scientist, Process Chemistry

Role Summary

Senior Scientist, Process Chemistry in Cambridge, MA. Lead multi-step route evaluation and development to establish commercial drug substance manufacturing processes, overseeing internal and outsourced laboratory activities and guiding collaborators.

Responsibilities

• Contribute to the design of novel and efficient synthetic pathways for drug substances undergoing clinical development
• Conduct and oversee route scouting in laboratory to demonstrate synthetic viability
• Use all imaginable chemistry tools and methods to develop and optimize commercial process for selected drug substance route (photochemistry, biocatalysis, flow chemistry, electrochemistry, on-line analysis/PAT, high-throughput experimentation, structural analysis, computational chemistry, etc.)
• Design, plan and execute experimental plans to optimize reaction, purification and isolation unit operations, guided by technical risk assessments, to deliver safe, efficient, robust and scalable drug substance manufacturing processes that perform reliably at intended scale in batch or continuous format
• Collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization
• Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development reports, project discussions and presentations
• Provide concise technical presentations to communicate work to project teams, cross functional teams and management. Document all work on projects and continuous improvements in eLNB experiments and summarize in technical reports
• Establish/extend external network by providing representation and leadership on academic, industrial, or government sponsored collaborations
• Champion continuous improvements through pursuit of scientific and technical innovations, workflow optimizations, and incorporation of digital tools

Qualifications

• Ph.D. in organic or synthetic chemistry.
• Knowledge in at least one of the following areas: advanced analytics, flow chemistry, high throughput experimentation.
• Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis.
• Computational capabilities and basic coding skills.
• Strong publication record in peer-reviewed journals.
• Excellent written and verbal communication skills.
• Ability to operate with flexibility in a dynamic environment and with tight deadlines.

Preferred Qualifications

• Post-doctoral experience.
• Proficiency with Microsoft suite.
• Familiarity with digital tools (e.g. Scifinder-n, and Reaxys) and advanced data analysis software (e.g. Spotfire).
• Design of experiment, statistical and/or thermo-kinetic modeling.
• Strategic and innovative thinker with a track record of fresh insightful thinking by developing creative approaches to processes and practices.
• French language skills.