Senior Scientist I or II, In Vitro Models, Translational Toxicology, Preclinical Safety

Role Summary

Senior Scientist I or II, In Vitro Models, Translational Toxicology, Preclinical Safety based in Cambridge, MA. Develop and apply in vitro models for safety assessment of novel drugs within Preclinical Safety/Translational Medicine, contribute to cross-functional translational toxicology efforts, and communicate results to relevant teams.

Responsibilities

• Contribute to the establishment and evaluation of novel in vitro models for the safety assessment of novel drugs.
• Maintain cell lines used for standard cardiotoxicity assays (Optional: proficiency in cell culture automation and electrophysiology ion channel assays).
• Explore and provide technical recommendations regarding external resources that could complement internal capabilities for the safety assessment of novel drugs using alternative in vitro models. Liaise with CROs on an ad-hoc basis for external activities.
• Collaborate and share experience with a team of bench scientists to perform experimental work, analyze data, identify and record the experimental output in electronic notebook. Show flexibility and adaptability when projects’ needs evolve.
• Present results to target teams and the broader PCS community.
• Organize lab operations across team members (ordering reagents, equipment maintenance, etc.).
• Proactively maintain current knowledge of scientific areas pertaining to advance in vitro model development, analytical technologies, and novel therapeutic modalities.
• Write SOPS where appropriate, ensure compliance to all protocols, procedures, and reporting.

Qualifications

• Essential: Degree (MS or BS) in a scientific field related to cell biology, in vitro complex models and possibly toxicology.
• Bachelor’s degree with a minimum of 5-6 plus years or Master’s degree and a minimum of 3 plus years relevant laboratory experience required.
• To be considered at the Senior Scientist II level must have a Bachelor’s with 8 plus years of experience or Master’s degree plus 5 years.
• Excellent communication, interpersonal and teamwork skills. Comfortable working in a matrix environment.
• Working knowledge of overall drug development process.

Skills

• Well-developed/effective organizational skills (planning, time management, etc.).
• Scientific curiosity, enthusiasm for continuous learning.
• Broad understanding of scientific and technical operations in investigative toxicology.
• Critical and creative problem-solving skills with independent thinking.

Education

• As above in Qualifications (MS or BS with relevant experience; advanced degree preferred for higher level).

Additional Requirements

• This is a dual level posting; final level and title determined by the hiring team based on skills and experience.