Senior Scientist I, Analytical Development - Mass Spectrometry tLNP CMC
AbbVie
June 30, 2026
On-site
North Chicago, IL
$96,500 - $183,500 USD yearly
Operations
Position Overview:
As the mass spectrometry SME in Analytical Development (Targeted LNP CMC Development), develop LC-MS methods for characterizing biotherapeutic products supporting tLNP development, with emphasis on mRNA and oligonucleotide analysis. Collaborate with global Analytical CMC and cross-functional partners.
Responsibilities:
- Operate, maintain, and troubleshoot mass spectrometry (Orbitrap, TOF) and liquid chromatography platforms and general lab equipment.
- Document instrument performance; organize maintenance; coordinate with service engineers.
- Lead characterization of mRNA critical quality attributes (5’ capping efficiency, 3’ polyA tail distribution, oligonucleotide sequence mapping).
- Provide analytical support across formulation, upstream/downstream process development, and manufacturing.
- Advance LC-MS characterization via innovative techniques to meet evolving needs and improve efficiency.
- Conduct sample prep and LC-MS analyses per SOPs; document procedures/results in an ELN.
- Author/review regulatory submission documents (e.g., IND and comparability studies).
Qualifications:
- Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field; 0–3 years industry experience.
- Strong plus: LC-MS analysis experience for mRNA, oligonucleotides, antibodies, and LNPs.
- Preferred: mRNA 5’ capping and 3’ polyA tail LC-MS analysis.
- Proficient in operating/troubleshooting LC-MS (including interface changes/cleaning).
- Experience with LCMS data acquisition/analysis software (e.g., XCalibur, Protein Metrics, FreeStyle, Skyline, BioPharma Finder, MassLynx).
- Organized, detail-oriented; able to work independently and collaborate; strong communication.
- Plus: additional mRNA/LNP-relevant analytical techniques.
Benefits (if applicable): paid time off, medical/dental/vision insurance, 401(k); eligible for short-term incentive programs.
As the mass spectrometry SME in Analytical Development (Targeted LNP CMC Development), develop LC-MS methods for characterizing biotherapeutic products supporting tLNP development, with emphasis on mRNA and oligonucleotide analysis. Collaborate with global Analytical CMC and cross-functional partners.
Responsibilities:
- Operate, maintain, and troubleshoot mass spectrometry (Orbitrap, TOF) and liquid chromatography platforms and general lab equipment.
- Document instrument performance; organize maintenance; coordinate with service engineers.
- Lead characterization of mRNA critical quality attributes (5’ capping efficiency, 3’ polyA tail distribution, oligonucleotide sequence mapping).
- Provide analytical support across formulation, upstream/downstream process development, and manufacturing.
- Advance LC-MS characterization via innovative techniques to meet evolving needs and improve efficiency.
- Conduct sample prep and LC-MS analyses per SOPs; document procedures/results in an ELN.
- Author/review regulatory submission documents (e.g., IND and comparability studies).
Qualifications:
- Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field; 0–3 years industry experience.
- Strong plus: LC-MS analysis experience for mRNA, oligonucleotides, antibodies, and LNPs.
- Preferred: mRNA 5’ capping and 3’ polyA tail LC-MS analysis.
- Proficient in operating/troubleshooting LC-MS (including interface changes/cleaning).
- Experience with LCMS data acquisition/analysis software (e.g., XCalibur, Protein Metrics, FreeStyle, Skyline, BioPharma Finder, MassLynx).
- Organized, detail-oriented; able to work independently and collaborate; strong communication.
- Plus: additional mRNA/LNP-relevant analytical techniques.
Benefits (if applicable): paid time off, medical/dental/vision insurance, 401(k); eligible for short-term incentive programs.