Senior Scientist, Human Genetics & Targets

Role Summary

We are seeking a highly motivated scientist to join the Human Genetics and Targets group within the Discovery Science department. This role focuses on discovering and validating novel drug targets for inflammatory diseases by leveraging cutting-edge genetics, -omics, and cellular approaches to drive therapeutic innovation in a collaborative, cross-functional environment. Position Location: onsite, Cambridge, MA.

Responsibilities

• Identify and validate therapeutic targets for inflammatory diseases, investigate disease mechanisms, and develop novel drug candidates.
• Extensive experience in 2D/3D cell assays with cell lines, stem cells/iPS, primary or immune cells (macrophage/microglia), and advanced models like organoids and co-cultures to assess immune responses and cell interactions.
• Perform mechanism-of-action studies using molecular and cellular methods such as cytokine analysis, Western blotting, flow cytometry, qPCR, immunofluorescence, and barrier assays.
• Engineer human cell models using CRISPR and siRNA technologies for functional screening and mechanistic studies.
• Collaborate with cross-functional teams.
• Stay current with scientific literature and advancements, contribute to the publication of research findings and present at scientific conference.
• Mentor/train junior colleagues.

Qualifications

• Required: B.S./M.S. in biological/biomedical sciences with a minimum of 7 years of hands-on experience in relevant fields; Recent Ph.D. graduates will also be considered.
• Required: Proficiency in mammalian cell culture (primary, stem, immune, barrier models etc.) and experience with complex 2D/3D in vitro models, multicellular systems such as organoids.
• Required: Solid background in molecular biology, immunology, and cell signaling, preferably with drug discovery experience in inflammatory or immune-related diseases.
• Required: Strong written and verbal communication, organizational, and interpersonal skills.
• Required: Proficient in problem-solving, data analysis, statistical/bioinformatics tools, and attention to detail.
• Required: Able to work independently and collaboratively, adapt to shifting priorities, learning agility, and maintain a strong passion for science.
• Preferred: Experience with advanced omics platforms such as spatial transcriptomics, single-cell RNA-seq or others, familiarity with machine learning, or systems biology approaches, population scale genetic datasets.
• Preferred: Experience in conducting genetic functional studies using primary human or rodent cells, and in vivo murine inflammation models.
• Preferred: Prior experience in inflammation research, particularly neuroinflammation or intestinal inflammation.
• Preferred: Demonstrated track record of scientific publications and conference presentations.

Education

• B.S./M.S. in biological/biomedical sciences