Senior Scientist - Cell Biology and Disease Modeling

Role Summary

Senior Scientist - Cell Biology and Disease Modeling, Cambridge, MA. Develop and implement cellular models that recapitulate human disease biology, with a focus on immune-mediated diseases, and use them to evaluate therapeutic candidate efficacy and mechanism of action. This role combines hands-on cell biology expertise with strategic project leadership to accelerate therapeutic discovery through physiologically relevant disease models.

Responsibilities

• Internalize, design and/or establish in vitro and ex vivo cellular models that reflect aspects of human disease pathophysiology, with a focus on immune-mediated diseases, and use to evaluate therapeutic candidate efficacy and mechanism-of-action
• Implement advanced cell culture techniques including 3D cultures, co-cultures, and patient-derived systems, with multi-omic, imaging and other read-outs
• Establish and validate cellular biomarker assays for translational research applications
• Develop and maintain cell biology laboratory capabilities, including equipment procurement and protocol standardization
• Collaborate with CROs to implement and transfer cellular model protocols
• Interface cross-functionally with research teams to integrate cellular biology data into therapeutic development decisions

Qualifications

• Required: Bachelor's + 8 years of relevant experience OR Master’s + 5 years of relevant experience OR Ph.D. + 3 years of relevant experience
• Required: 2+ years of biopharma industry experience in cellular model development
• Required: Strong track record in establishing disease-relevant cellular systems
• Required: Experience with multi-omics, cellular imaging, flow cytometry, and/or high-content analysis
• Required: Project management experience including timeline and budget oversight
• Preferred: Relevant experience in biopharma is preferred
• Preferred: Experience with primary human immune and other cells and/or iPSC-derived cellular models
• Preferred: Familiarity with CRISPR gene editing for cellular model development
• Preferred: Experience with microfluidic or organ-on-chip technologies
• Preferred: Experience managing CRO relationships for cellular biology work
• Preferred: Equipment procurement and cell biology lab setup experience
• Preferred: Demonstrated scientific creativity in disease model development
• Preferred: Experience with mechanistic in vivo models of disease

Skills

• Deep understanding of cellular biology and human disease mechanisms
• Strong analytical and data interpretation skills
• Excellence in written and verbal communication of complex biological data
• Ability to work effectively in a fast-paced, collaborative environment
• Entrepreneurial mindset with calculated risk-taking ability