Senior Principal Scientist, Clinical Research - Immunology/Dermatology
Merck
September 02, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Senior Director (Sr. Principal Scientist) — Immunology clinical research strategy and late-stage development.
Responsibilities:
- Strategically plan and direct clinical research for investigational immunology compounds across the full clinical development cycle (indication selection, study design, initiation, execution, monitoring, analysis, regulatory filing, and publication).
- Evaluate pre-clinical and translational work to develop early clinical development plans and Investigational New Drug (IND) applications.
- Support business development assessments for external opportunities to expand the immunology pipeline.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor and manage conduct of ongoing and new clinical trials.
- Analyze and summarize clinical findings to support safety/efficacy decisions, new drug applications, clinical study reports, and publications.
- Participate in internal and joint internal/external research project teams.
- Supervise Clinical Scientists; collaborate cross-functionally (commercialization, regulatory affairs, statistics, manufacturing) to manage clinical development projects.
- Maintain scientific knowledge via awareness of new research methods/findings, identify strong investigators, build external collaborations (rheumatology, gastroenterology, dermatology, pulmonary, rare diseases), and attend scientific meetings.
- Author development documents and presentations; facilitate global external collaborations; travel ~20%.
Qualifications:
- MD, DO, MD/PhD, or DO/PhD.
- 2+ or 3 (phase 2 or 3) immunology clinical trial design/execution experience.
- Minimum 3 years clinical medicine experience.
- Minimum 5 years industry drug development experience.
- Demonstrated scientific scholarship and achievement.
- Strong interpersonal skills and cross-functional collaboration.
Required Skills:
- Clinical decision making, clinical development, clinical documentation, clinical judgment, data analysis, dermatology, drug development, immunology.
Preferred Skills:
- Current employees/contingent workers apply via the company site.
Application:
- Apply at https://jobs.merck.com/us/en (or Workday Jobs Hub). Apply by the posting deadline shown on the posting. Requisition ID: R416082.
Responsibilities:
- Strategically plan and direct clinical research for investigational immunology compounds across the full clinical development cycle (indication selection, study design, initiation, execution, monitoring, analysis, regulatory filing, and publication).
- Evaluate pre-clinical and translational work to develop early clinical development plans and Investigational New Drug (IND) applications.
- Support business development assessments for external opportunities to expand the immunology pipeline.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor and manage conduct of ongoing and new clinical trials.
- Analyze and summarize clinical findings to support safety/efficacy decisions, new drug applications, clinical study reports, and publications.
- Participate in internal and joint internal/external research project teams.
- Supervise Clinical Scientists; collaborate cross-functionally (commercialization, regulatory affairs, statistics, manufacturing) to manage clinical development projects.
- Maintain scientific knowledge via awareness of new research methods/findings, identify strong investigators, build external collaborations (rheumatology, gastroenterology, dermatology, pulmonary, rare diseases), and attend scientific meetings.
- Author development documents and presentations; facilitate global external collaborations; travel ~20%.
Qualifications:
- MD, DO, MD/PhD, or DO/PhD.
- 2+ or 3 (phase 2 or 3) immunology clinical trial design/execution experience.
- Minimum 3 years clinical medicine experience.
- Minimum 5 years industry drug development experience.
- Demonstrated scientific scholarship and achievement.
- Strong interpersonal skills and cross-functional collaboration.
Required Skills:
- Clinical decision making, clinical development, clinical documentation, clinical judgment, data analysis, dermatology, drug development, immunology.
Preferred Skills:
- Current employees/contingent workers apply via the company site.
Application:
- Apply at https://jobs.merck.com/us/en (or Workday Jobs Hub). Apply by the posting deadline shown on the posting. Requisition ID: R416082.