Senior Principal Scientist, Clinical Research - Immunology/Dermatology
Merck
September 02, 2026
Remote friendly (North Wales, PA)
United States
Clinical Research and Development
Responsibilities:
- Strategically plan and direct clinical research activities for investigational compounds in Immunology, including full clinical development cycle (indication selection, study design, initiation, execution, monitoring, analysis, regulatory filing, and publication).
- Evaluate pre-clinical and translational work to develop early clinical plans and IND applications.
- Support business development assessments to grow the Immunology pipeline.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor and manage ongoing and new clinical trials.
- Analyze and summarize clinical findings to support safety/efficacy decisions and outputs including regulatory submissions, clinical study reports, and publication.
- Participate in internal and joint internal/external research project teams for new compounds.
- Supervise Clinical Scientists; collaborate cross-functionally (commercialization, regulatory, statistics, manufacturing) to manage clinical development projects.
Scientific/Operational Development:
- Maintain scientific knowledge; identify strong investigators; build collaborations with external experts in relevant specialties/disease areas.
- Attend scientific meetings.
Qualifications:
- Education: M.D., D.O., M.D./Ph.D, or D.O./PhD.
- Required: Phase 2 or 3 clinical trial design/execution in Immunology; 3+ years clinical medicine; 5+ years industry drug development; demonstrated scientific scholarship; strong interpersonal skills and cross-functional collaboration.
Required/Preferred Skills:
- Required skills: Clinical Decision Making, Clinical Development, Clinical Documentation, Clinical Judgment, Data Analysis, Dermatology, Drug Development, Immunology.
Application:
- Apply via https://jobs.merck.com/us/en (deadline stated on posting). Requisition ID: R416082.
- Strategically plan and direct clinical research activities for investigational compounds in Immunology, including full clinical development cycle (indication selection, study design, initiation, execution, monitoring, analysis, regulatory filing, and publication).
- Evaluate pre-clinical and translational work to develop early clinical plans and IND applications.
- Support business development assessments to grow the Immunology pipeline.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor and manage ongoing and new clinical trials.
- Analyze and summarize clinical findings to support safety/efficacy decisions and outputs including regulatory submissions, clinical study reports, and publication.
- Participate in internal and joint internal/external research project teams for new compounds.
- Supervise Clinical Scientists; collaborate cross-functionally (commercialization, regulatory, statistics, manufacturing) to manage clinical development projects.
Scientific/Operational Development:
- Maintain scientific knowledge; identify strong investigators; build collaborations with external experts in relevant specialties/disease areas.
- Attend scientific meetings.
Qualifications:
- Education: M.D., D.O., M.D./Ph.D, or D.O./PhD.
- Required: Phase 2 or 3 clinical trial design/execution in Immunology; 3+ years clinical medicine; 5+ years industry drug development; demonstrated scientific scholarship; strong interpersonal skills and cross-functional collaboration.
Required/Preferred Skills:
- Required skills: Clinical Decision Making, Clinical Development, Clinical Documentation, Clinical Judgment, Data Analysis, Dermatology, Drug Development, Immunology.
Application:
- Apply via https://jobs.merck.com/us/en (deadline stated on posting). Requisition ID: R416082.