Senior Principal Scientist, Clinical Research - Immunology/Dermatology
Merck
September 02, 2026
Remote friendly (Rahway, NJ)
United States
Clinical Research and Development
Senior Director (Sr. Principal Scientist) – Immunology
Responsibilities:
- Strategically plan and direct late-stage clinical research for investigational Immunology compounds across the clinical development lifecycle (disease indication selection, study design, initiation, execution, monitoring, analysis, regulatory filing, and publication).
- Evaluate pre-clinical/translational work to generate early clinical development plans and INDs.
- Support business development assessments for external opportunities to grow the Immunology pipeline.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor and manage ongoing/new clinical trials.
- Analyze/summarize clinical findings to support safety/efficacy decisions, regulatory submissions, clinical study reports, and publications.
- Participate in internal and joint internal/external research teams; supervise Clinical Scientists.
- Collaborate cross-functionally with commercialization, regulatory affairs, statistics, and manufacturing.
- Maintain scientific expertise (monitor scientific developments, identify investigators, build collaborations in relevant therapeutic areas, attend scientific meetings).
- Author development documents/presentations/budgets/position papers; facilitate global collaborations; travel ~20%.
Qualifications:
- M.D., D.O., M.D./Ph.D., or D.O./PhD.
- Experience designing and/or executing Phase 2 or 3 Immunology clinical trials.
- 3+ years clinical medicine experience.
- 5+ years industry drug development experience.
Required skills:
- Clinical decision making, clinical development/documentation/judgment, data analysis, drug development, Immunology.
Preferred skills:
- Not specified.
Benefits (if applicable):
- Annual bonus and long-term incentive (if applicable); medical/dental/vision, retirement (401k), paid holidays/vacation, compassionate and sick days.
Apply:
- Apply via jobs.merck.com (application deadline stated on posting).
Responsibilities:
- Strategically plan and direct late-stage clinical research for investigational Immunology compounds across the clinical development lifecycle (disease indication selection, study design, initiation, execution, monitoring, analysis, regulatory filing, and publication).
- Evaluate pre-clinical/translational work to generate early clinical development plans and INDs.
- Support business development assessments for external opportunities to grow the Immunology pipeline.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor and manage ongoing/new clinical trials.
- Analyze/summarize clinical findings to support safety/efficacy decisions, regulatory submissions, clinical study reports, and publications.
- Participate in internal and joint internal/external research teams; supervise Clinical Scientists.
- Collaborate cross-functionally with commercialization, regulatory affairs, statistics, and manufacturing.
- Maintain scientific expertise (monitor scientific developments, identify investigators, build collaborations in relevant therapeutic areas, attend scientific meetings).
- Author development documents/presentations/budgets/position papers; facilitate global collaborations; travel ~20%.
Qualifications:
- M.D., D.O., M.D./Ph.D., or D.O./PhD.
- Experience designing and/or executing Phase 2 or 3 Immunology clinical trials.
- 3+ years clinical medicine experience.
- 5+ years industry drug development experience.
Required skills:
- Clinical decision making, clinical development/documentation/judgment, data analysis, drug development, Immunology.
Preferred skills:
- Not specified.
Benefits (if applicable):
- Annual bonus and long-term incentive (if applicable); medical/dental/vision, retirement (401k), paid holidays/vacation, compassionate and sick days.
Apply:
- Apply via jobs.merck.com (application deadline stated on posting).