Senior Manager, Commercial Supply Planning

Role Summary

Senior Manager, Commercial Supply Planning — support upcoming Commercial product launch and establish scalable processes for global commercial supply operations. Develop and lead the execution of supply plans across external Drug Substance and Drug Product manufacturing network, ensuring SAP reflects real-time activity within the commercial supply chain. Reports to Head of Supply Chain Planning and enables launch readiness and post-launch execution.

Responsibilities

• Develop and maintain a rolling production plan aligned with forecast, safety stock, and lot-sizing constraints.
• Convert demand forecasts into executable production and packaging plans with CMOs.
• Monitor and manage launch readiness, including DS/DP inventory targets, expiry windows, and campaign timing.
• Partner with QA, Manufacturing, and Regulatory to ensure supply strategy supports release, labeling, and distribution needs.
• Support Sales & Operations Planning (S&OP) process with capacity scenarios, risk assessments, and metrics.
• Identify and escalate risks related to supply shortages, delays, or over-production.
• Manage Denali‚Äôs Sales & Operations Execution (S&OE) process in conjunction with CMC Program Leader to ensure adherence to production plan across both internal and external stakeholders.
• Create, manage, and monitor the end-to-end material procurement process including Purchase Requisitions, Purchase Orders, and Goods Receipts within SAP.
• Reconcile SAP inventory positions with external batch and shipment data, flagging discrepancies and driving resolution.
• Track and input batch-level data such as shelf life, release dates, and sampling requirements, and destruction logs.

Qualifications

• 5+ to 10 years in supply or production planning, preferably in biotech/pharma.
• Direct experience working with external manufacturing partners (CMOs/3PLs).
• Strong Excel and analytical skills.
• Proficient in ERP systems with hands-on experience in production planning, materials management, and inventory management modules (e.g., order creation, goods receipt, and batch tracking transactions).
• Strong understanding of external manufacturing (CMOs) and batch-based planning.
• Proven ability to manage multiple priorities, timelines, and data streams across functions.
• High proficiency in Excel (pivot tables, lookups, simple macros).

Preferred

• Experience supporting a commercial product launch in a regulated industry.
• Familiarity with GMP inventory practices and batch traceability.
• Comfortable navigating cross-functional discussions across Quality, Regulatory, and CMC.