Senior Director, Program Management

Role Summary

We are seeking a strategic and operationally-savvy leader to oversee and drive the program management function at Mirum, building best-in-class program management practices and strategic approaches to drive results. This leader will establish program-related processes, systems, and templates to enable portfolio-level oversight and decision-making, and will lead and mentor a team of program management professionals while fostering cross-functional partnerships to maximize portfolio value.

Responsibilities

• Lead a high-performing Project Management Office that supports strategic planning and execution across all development programs.
• Establish and manage program governance to enable prioritization of resources and activities, including the annual operating plan process with FP&A.
• Develop, implement and refine PMO processes, frameworks and tools (timelines, stage-gates, communication plans, resource planning, budgeting, decision-making, etc.).
• Serve as a strategic partner and communicator with senior leadership: provide program status, decision-support, trade-offs, and portfolio linkage.
• Facilitate decision-making processes, including risk mitigation strategies and scenario planning.
• Identify key hurdles across programs in partnership with program managers.
• Identify, assess and mitigate portfolio-level program risks and dependencies; escalate issues as needed.
• Maintain continuous communication with Program Leads to ensure timely support and proactive involvement in program dynamics and team performance.
• Drive cross-functional collaboration to align stakeholders (clinical, regulatory, CMC, finance, commercial) around program strategy and deliverables.
• Mentor and develop program managers, fostering a culture of accountability, innovation, and continuous improvement.
• Coach and mentor team members on roles, interdependencies, action plans, and executive-facing presentations.
• Actively resolve issues and elevate concerns with urgency to promote rapid improvement and responsiveness.
• Serve as the Program Manager for one of Mirum‚Äôs programs or during corporate development evaluation of potential new assets, as needed.

Qualifications

• Bachelor‚Äôs degree in life sciences, engineering or related field required; advanced degree (MS, PhD, MBA) strongly preferred.
• 10+ years of experience in the biotech or pharmaceutical industry, with substantive exposure to drug development.
• Demonstrated portfolio and program management experience with cross-functional and global teams, including milestone budgeting and resourcing management.
• Previous experience building a PMO is a plus.
• Knowledge of therapeutic development lifecycle including non-clinical, clinical, CMC/manufacturing, regulatory and commercial interface.

Skills

• Excellent leadership, communication and interpersonal skills; ability to influence without direct authority and navigate matrix environments.
• Strong analytical and problem-solving capabilities; comfortable with ambiguity and dynamic change.
• Familiarity with program management tools and frameworks (e.g., MS Project, Smartsheet, stage-gate processes).

Education

• Bachelor‚Äôs degree in life sciences, engineering or related field; advanced degree (MS, PhD, MBA) strongly preferred.