Senior Director, Program Management
Dyne Therapeutics
August 31, 2026
On-site
Waltham, MA
Operations
Role Summary
The Senior Director, Program Management (PM) drives execution across cross-functional drug development activities for one or more molecules. Partners with the Program Team Leader (PTL) and functional experts to ensure plans include appropriate detail and risk awareness, integrating functional plans into a cohesive program strategy. Maintains an agile mindset to incorporate emerging rare-disease data.
Primary Responsibilities
- Lead operations of one or more cross-functional teams (priorities, goals, resources) and maintain a sustainable, collaborative environment.
- Partner with PTL to identify short-, medium-, and long-term priorities.
- Drive execution of program vision and strategy.
- Facilitate creation and maintenance of core program documents: TPP, Clinical Development Plan, Regulatory Strategy, Supply Strategy.
- Ensure non-clinical, clinical, regulatory, and commercialization plans align with TPP and program strategy.
- Develop efficient plans optimizing quality, speed, and cost.
- Ensure timely, clear program decisions through governance and stakeholder engagement.
- Maintain detailed cross-functional plans and visual summaries for accountability.
- Communicate program status, priorities, risks, and needs to leadership and stakeholders.
- Evolve Program Management discipline to support organizational growth and a disease product portfolio.
- Stay current on R&D developments in muscle diseases and oligonucleotide drug discovery/development.
- Foster a culture of collaboration, innovation, and continuous improvement.
Education & Skills Requirements
- Bachelor’s degree in science or related field; advanced degree or MBA preferred.
- 15+ years biotech/pharma drug development experience with increasing responsibility.
- Late-stage clinical development and commercial stage program experience required.
- Neuromuscular disease experience a plus.
- Excellent communication (verbal, written, presentation); influence without direct authority.
- Proficient with Microsoft Office 365, Smartsheet, and PM collaboration tools.
- Strong cross-functional, matrix teamwork and high-stakes, data-driven decision-making.
- Experience leading complex projects under ambiguity and in fast-paced environments.
Location
Waltham, MA (not remote).
The Senior Director, Program Management (PM) drives execution across cross-functional drug development activities for one or more molecules. Partners with the Program Team Leader (PTL) and functional experts to ensure plans include appropriate detail and risk awareness, integrating functional plans into a cohesive program strategy. Maintains an agile mindset to incorporate emerging rare-disease data.
Primary Responsibilities
- Lead operations of one or more cross-functional teams (priorities, goals, resources) and maintain a sustainable, collaborative environment.
- Partner with PTL to identify short-, medium-, and long-term priorities.
- Drive execution of program vision and strategy.
- Facilitate creation and maintenance of core program documents: TPP, Clinical Development Plan, Regulatory Strategy, Supply Strategy.
- Ensure non-clinical, clinical, regulatory, and commercialization plans align with TPP and program strategy.
- Develop efficient plans optimizing quality, speed, and cost.
- Ensure timely, clear program decisions through governance and stakeholder engagement.
- Maintain detailed cross-functional plans and visual summaries for accountability.
- Communicate program status, priorities, risks, and needs to leadership and stakeholders.
- Evolve Program Management discipline to support organizational growth and a disease product portfolio.
- Stay current on R&D developments in muscle diseases and oligonucleotide drug discovery/development.
- Foster a culture of collaboration, innovation, and continuous improvement.
Education & Skills Requirements
- Bachelor’s degree in science or related field; advanced degree or MBA preferred.
- 15+ years biotech/pharma drug development experience with increasing responsibility.
- Late-stage clinical development and commercial stage program experience required.
- Neuromuscular disease experience a plus.
- Excellent communication (verbal, written, presentation); influence without direct authority.
- Proficient with Microsoft Office 365, Smartsheet, and PM collaboration tools.
- Strong cross-functional, matrix teamwork and high-stakes, data-driven decision-making.
- Experience leading complex projects under ambiguity and in fast-paced environments.
Location
Waltham, MA (not remote).