Senior Director, Program Management
Dyne Therapeutics
June 27, 2026
On-site
Waltham, MA
Operations
Role Summary
Senior Director, Program Management (PM) for cross-functional drug development execution for one or more molecules.
Based in Waltham, MA (not remote).
Primary Responsibilities
- Lead operations of one or more cross-functional teams (priorities, goal achievement, resources) and sustain a collaborative environment.
- Partner with the PTL to define short/medium/long-term team priorities and plans.
- Drive execution of program vision and strategy for bringing medicines to patients.
- Facilitate creation/maintenance of core program strategy documents: Target Product Profile (TPP), Clinical Development Plan, Regulatory Strategy, Supply Strategy.
- Ensure non-clinical, clinical, regulatory, and commercialization strategies align with the TPP and overall program strategy.
- Build efficient development/commercialization plans optimized for quality, speed, and cost.
- Ensure timely, clear program decisions via governance/forums and stakeholder engagement.
- Maintain detailed cross-functional plans and visual summaries to build accountability.
- Communicate program status, priorities, risks, and needs to leadership and stakeholders.
- Evolve Program Management discipline with Head of Program Management.
- Stay current on R&D developments in muscle diseases and oligonucleotide therapeutics.
- Foster collaboration, innovation, discovery, and continuous improvement.
Education and Skills Requirements
- BS in science or related; advanced degree or MBA preferred.
- 15+ years biotech/pharma drug development experience with increasing responsibility.
- Late-stage clinical and commercial-stage program experience required; neuromuscular experience a plus.
- Strong communication; cross-functional influence without authority; data-driven decision-making.
- Proficient with Microsoft Office 365 and Smartsheet/PM tools.
- Ability to operate in matrix teams; urgency; comfort with ambiguity; lead without authority.
MA Pay Range: $233,000–$285,000 USD.
Senior Director, Program Management (PM) for cross-functional drug development execution for one or more molecules.
Based in Waltham, MA (not remote).
Primary Responsibilities
- Lead operations of one or more cross-functional teams (priorities, goal achievement, resources) and sustain a collaborative environment.
- Partner with the PTL to define short/medium/long-term team priorities and plans.
- Drive execution of program vision and strategy for bringing medicines to patients.
- Facilitate creation/maintenance of core program strategy documents: Target Product Profile (TPP), Clinical Development Plan, Regulatory Strategy, Supply Strategy.
- Ensure non-clinical, clinical, regulatory, and commercialization strategies align with the TPP and overall program strategy.
- Build efficient development/commercialization plans optimized for quality, speed, and cost.
- Ensure timely, clear program decisions via governance/forums and stakeholder engagement.
- Maintain detailed cross-functional plans and visual summaries to build accountability.
- Communicate program status, priorities, risks, and needs to leadership and stakeholders.
- Evolve Program Management discipline with Head of Program Management.
- Stay current on R&D developments in muscle diseases and oligonucleotide therapeutics.
- Foster collaboration, innovation, discovery, and continuous improvement.
Education and Skills Requirements
- BS in science or related; advanced degree or MBA preferred.
- 15+ years biotech/pharma drug development experience with increasing responsibility.
- Late-stage clinical and commercial-stage program experience required; neuromuscular experience a plus.
- Strong communication; cross-functional influence without authority; data-driven decision-making.
- Proficient with Microsoft Office 365 and Smartsheet/PM tools.
- Ability to operate in matrix teams; urgency; comfort with ambiguity; lead without authority.
MA Pay Range: $233,000–$285,000 USD.