Senior Director, Clinical Scientist
Madrigal Pharmaceuticals
September 02, 2026
Remote friendly (Conshohocken, PA)
United States
Clinical Research and Development
Senior Director, Clinical Scientist (MASH)
Key Responsibilities
- Design and develop clinical trial protocols (rationale, objectives, endpoints, eligibility criteria).
- Author/review key clinical and regulatory documents (investigator brochures, informed consent forms, CSRs, regulatory submissions).
- Provide scientific input during execution (protocol amendments, site engagement, data reviews, ongoing study support).
- Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure data integrity and trial quality.
- Conduct data reviews and support data interpretation with biostatistics/medical.
- Support regulatory submission documentation, health authority meetings, and internal governance presentations.
- Stay current on MASH/NASH therapeutic trends, competitive landscape, and regulatory guidance.
- Participate in cross-functional meetings; contribute to development strategies and timelines.
Experience and Qualifications
- Advanced degree (PhD, MD, PharmD, or equivalent) required (Master’s with relevant experience may be considered).
- 10+ years in clinical development/research in pharma/biotech.
- 15+ years relevant experience.
- Strong preference: liver disease, metabolic disorders, or MASH/NASH.
- Solid ICH/GCP and global clinical trial regulation knowledge.
- Ability to synthesize complex data and communicate clearly.
- Strong organizational and project management; collaborative mindset.
Preferred Attributes
- Fast-paced biotech experience with small agile teams.
- Familiarity with liver endpoints (histology, imaging, non-invasive biomarkers).
- Regulatory interaction/submission experience a plus.
Benefits/Pay (as stated)
- Base pay estimate: $260,000–$318,000/year; plus bonus/equity.
- Full-time benefits: PTO, medical/dental/vision, life/disability, 401(k), and other voluntary benefits.
Application Instructions
- Apply via the Madrigal Careers site (accepted on an ongoing basis).
Key Responsibilities
- Design and develop clinical trial protocols (rationale, objectives, endpoints, eligibility criteria).
- Author/review key clinical and regulatory documents (investigator brochures, informed consent forms, CSRs, regulatory submissions).
- Provide scientific input during execution (protocol amendments, site engagement, data reviews, ongoing study support).
- Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure data integrity and trial quality.
- Conduct data reviews and support data interpretation with biostatistics/medical.
- Support regulatory submission documentation, health authority meetings, and internal governance presentations.
- Stay current on MASH/NASH therapeutic trends, competitive landscape, and regulatory guidance.
- Participate in cross-functional meetings; contribute to development strategies and timelines.
Experience and Qualifications
- Advanced degree (PhD, MD, PharmD, or equivalent) required (Master’s with relevant experience may be considered).
- 10+ years in clinical development/research in pharma/biotech.
- 15+ years relevant experience.
- Strong preference: liver disease, metabolic disorders, or MASH/NASH.
- Solid ICH/GCP and global clinical trial regulation knowledge.
- Ability to synthesize complex data and communicate clearly.
- Strong organizational and project management; collaborative mindset.
Preferred Attributes
- Fast-paced biotech experience with small agile teams.
- Familiarity with liver endpoints (histology, imaging, non-invasive biomarkers).
- Regulatory interaction/submission experience a plus.
Benefits/Pay (as stated)
- Base pay estimate: $260,000–$318,000/year; plus bonus/equity.
- Full-time benefits: PTO, medical/dental/vision, life/disability, 401(k), and other voluntary benefits.
Application Instructions
- Apply via the Madrigal Careers site (accepted on an ongoing basis).