Spyre Therapeutics

Spyre Therapeutics is a biotechnology company that aims to create next-generation inflammatory bowel disease (IBD) and other immune-mediated disease products by combining best-in-class antibody engineering, rational therapeutic combinations, and precision medicine approaches. Spyre’s pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23.

Role Summary

The Senior Director of Clinical Pharmacology will play a pivotal role in leading our clinical pharmacology efforts to advance the development of our cutting-edge antibody portfolio. This position requires a strategic leader who can integrate clinical pharmacology and pharmacokinetics/pharmacodynamics (PK/PD) strategies into our drug development programs to ensure efficacy, safety, and regulatory success.

Key Responsibilities

• Lead the strategic planning and execution of clinical pharmacology studies, including PK/PD modeling, dose-response analysis, and bioequivalence studies.
• Collaborate closely with cross-functional teams, including clinical development, non-clinical development, DMPK, regulatory affairs, and clinical operations, to ensure alignment and integration of clinical pharmacology principles throughout the drug development process.
• Oversee the development and implementation of modeling and simulation strategies to predict drug behavior, optimize dosing, and support clinical trial design.
• Provide expert guidance on clinical pharmacology topics to regulatory submissions and interactions with health authorities worldwide.
• Stay abreast of emerging trends and regulations in clinical pharmacology and antibody development to ensure Spyre Therapeutics remains at the cutting edge.

Ideal Candidate

• Ph.D. in Pharmacology, Pharmaceutical Sciences, or related field, with a strong focus on clinical pharmacology.
• A minimum of 10 years of experience in clinical pharmacology within the pharmaceutical or biotechnology industry, with significant experience in antibody development.
• Experience with extended half-life biologics and/or combination products desirable.
• Proven track record of accomplishment in drug development, from early-stage research through to regulatory submission and approval.
• Extensive experience with regulatory submissions and interactions with health authorities, particularly the FDA and EMA.
• Strong analytical and problem-solving skills, with expertise in PK/PD modeling and simulation.
• Excellent communication and interpersonal skills, with the ability to motivate teams and collaborate effectively across functions.

What We Offer

• Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly.
• Market-competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
• Unlimited PTO
• Two, one-week company-wide shutdowns each year.
• Commitment to growing you professionally and providing access to resources to further your development.
• 100% remote team with frequent in-person meetings to build relationships and problem solve.

Salary Range

The expected salary range offer for this role is $255,000 to $295,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.

Diversity Commitment

As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.

Job Scams Awareness

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.

Job Postings

Please also be aware that all job postings will be listed on our website at spyre.com/careers/.