Senior Associate Scientist, LC/LC-MS
Bristol Myers Squibb
June 26, 2026
Remote friendly (Cambridge, MA)
United States
Operations
Position Summary:
Senior Associate Scientist with expertise in analytical method development to support novel RNA therapeutics. Use liquid chromatography and LC/MS to design, develop, and execute analytical methods for characterization of lipids, antibodies, and RNA-based modalities across discovery and development stages.
Responsibilities:
- Independently design, develop, and optimize analytical methods using LC and LC/MS to characterize RNA therapeutics, lipid nanoparticles, and related components.
- Lead method lifecycle activities (development, qualification, validation, and transfer to internal/external labs such as CROs/CDMOs) and author SOPs, protocols, and technical reports.
- Collaborate cross-functionally to support analytical development, troubleshoot issues, and enable program milestones.
- Troubleshoot analytical challenges; interpret data and recommend solutions to improve assay performance and robustness.
- Perform/oversee routine and non-routine analytical testing, including data review and verification for quality/integrity/compliance.
- Operate, maintain, and troubleshoot LC and MS instrumentation.
- Analyze and communicate complex analytical data via reports and presentations.
Qualifications:
- B.S./M.S. in Analytical Chemistry, Biochemistry, or related field with 2+ years CMC-related experience; PhD candidates with appropriate experience considered.
- LC-MS method development, impurity characterization, and structural elucidation using high-resolution MS.
- LNP drug products, antibodies, and RNA/oligonucleotide analysis preferred.
- Ability to manage multiple projects in a fast-paced environment.
- Strong technical writing for reports/protocols/regulatory documentation.
- Familiarity with regulatory expectations (e.g., ICH, FDA) for analytical data/submissions.
Compensation:
Cambridge, MA, US: $96,010–$116,339 (starting range; final based on experience).
Senior Associate Scientist with expertise in analytical method development to support novel RNA therapeutics. Use liquid chromatography and LC/MS to design, develop, and execute analytical methods for characterization of lipids, antibodies, and RNA-based modalities across discovery and development stages.
Responsibilities:
- Independently design, develop, and optimize analytical methods using LC and LC/MS to characterize RNA therapeutics, lipid nanoparticles, and related components.
- Lead method lifecycle activities (development, qualification, validation, and transfer to internal/external labs such as CROs/CDMOs) and author SOPs, protocols, and technical reports.
- Collaborate cross-functionally to support analytical development, troubleshoot issues, and enable program milestones.
- Troubleshoot analytical challenges; interpret data and recommend solutions to improve assay performance and robustness.
- Perform/oversee routine and non-routine analytical testing, including data review and verification for quality/integrity/compliance.
- Operate, maintain, and troubleshoot LC and MS instrumentation.
- Analyze and communicate complex analytical data via reports and presentations.
Qualifications:
- B.S./M.S. in Analytical Chemistry, Biochemistry, or related field with 2+ years CMC-related experience; PhD candidates with appropriate experience considered.
- LC-MS method development, impurity characterization, and structural elucidation using high-resolution MS.
- LNP drug products, antibodies, and RNA/oligonucleotide analysis preferred.
- Ability to manage multiple projects in a fast-paced environment.
- Strong technical writing for reports/protocols/regulatory documentation.
- Familiarity with regulatory expectations (e.g., ICH, FDA) for analytical data/submissions.
Compensation:
Cambridge, MA, US: $96,010–$116,339 (starting range; final based on experience).