Senior Associate Scientist

Role Summary

Senior Associate Scientist in Tarrytown, NY responsible for developing and characterizing cellular and animal models to test novel therapeutics for neurodegenerative diseases. You will collect disease-relevant tissue, perform downstream processing and analyses (biochemical assays, tissue sectioning, immunohistochemistry, and microscopy), and design cell-based assays and other technologies to understand neurodegeneration. You will analyze data, participate in research studies, and present findings internally and externally in a collaborative, cross-functional team. Local telecommuting may be permitted up to 1 day per week.

Responsibilities

• Develop and characterize cellular and mouse models of neurological and neurodegenerative disease.
• Collect disease-relevant tissue from animal models and perform downstream processing including biochemical analysis, tissue sectioning, immunohistochemistry, and microscopy.
• Design and implement cell-based assays and other novel technologies to study mechanisms of neurodegeneration.
• Analyze and evaluate data; present findings and contribute to cross-functional team discussions.
• Participate in research studies to understand biology behind neurodegenerative diseases (e.g., ALS); present data internally and externally.
• Collaborate in a cross-functional team environment; may involve internal and external presentations.
• Local telecommuting permitted up to 1 day per week.

Qualifications

• Required: Bachelor's degree in Biology, Molecular Biology, Neuroscience, Biotechnology or related field; 1 year of experience in the biotechnology industry.
• Experience with: Development and characterization of cellular and mouse models of neurological and neurodegenerative disease; handling of neonatal and adult mice; intracerebroventricular (ICV) injection of adeno-associated virus (AAV) into neonatal mouse pups; mouse dissection including microdissection of sub-regions of CNS tissue; processing cell and tissue samples for biochemical analysis (Western blot, ProteinSimple Wes/PeggySue, ELISA, MSD); DNA and RNA isolation and real-time qPCR; downstream processing of mouse tissue (sectioning, immunostaining, immunohistochemistry, advanced microscopy such as confocal imaging and high-throughput plate readers like Opera Phoenix); in vitro cell culture systems including transformed cell lines and human iPSCs with neuronal differentiation; data analysis using Halo, GraphPad Prism, Excel and PowerPoint; compiling data into presentation formats and presenting work internally and externally in cross-functional discussions.

Education

• Bachelor's degree in Biology, Molecular Biology, Neuroscience, Biotechnology or related field.

Skills

• Cell culture (transformed cell lines and human iPSC-derived neurons)
• In vivo and ex vivo mouse model work, including dissection and ICV injections
• Molecular biology and biochemistry techniques (Western blot, ELISA, MSD, capillary electrophoresis)
• Histology and immunohistochemistry; confocal imaging; high-throughput microscopy
• Data analysis software: Halo, GraphPad Prism, Excel, PowerPoint
• Strong communication and collaboration in cross-functional teams

Additional Requirements

• Local telecommuting permitted up to 1 day per week.