Senior Analytical Scientist

Role Summary

Senior Analytical Scientist at Stoke Therapeutics, joining the Analytical and Formulation Sciences team. The role focuses on UPLC method development and mass spectrometry-based characterization of oligonucleotides and their conjugates to support the development of oligonucleotide-based therapeutics. This position reports to the Director, CMC and is based in Bedford, MA with approximately 5% travel.

Responsibilities

• Develop, optimize, and validate UPLC methods for the analysis of oligonucleotides and their conjugates.
• Conduct mass spectrometry (LC-MS, HRMS, MS/MS) analyses to characterize oligonucleotide and its conjugates.
• Interpret analytical data to support product development, stability studies, and release testing.
• Collaborate with cross-functional teams including Process Development, Quality, and Regulatory Affairs.
• Author technical reports, method development summaries, and regulatory submissions (e.g., IND, BLA).
• Perform routine formulation preparation and characterization of oligonucleotide drug products for preclinical studies.

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 6+ years of relevant industry experience; or MS with 10+ years of experience; or Bachelor's with 16+ years of experience.
• Proven experience in UPLC method development for oligonucleotides or nucleic acid-based therapeutics.
• Strong expertise with mass spectrometry for structural and quantitative analysis of oligonucleotide and conjugates is desired.
• Strong data analysis skills and proficiency with analytical software (e.g., Empower, MassLynx, Xcalibur).
• Excellent communication, documentation, and organizational skills.
• Ability to work independently and collaboratively in a fast-paced environment.
• Knowledge of ICH guidelines and regulatory expectations for analytical method validation.

Additional Requirements

• Location: Bedford, MA (based in Bedford).
• Travel: approximately 5% travel.