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Scientist - Rare Disease Biology

Amgen
September 12, 2026
Full-time
Remote friendly (South San Francisco, CA)
Worldwide
Clinical Research and Development
Role: Scientist in Rare Disease Biology focused on autoimmune and fibro-inflammatory disorders, contributing to discovery and advancement of therapies for conditions like Thyroid Eye Disease. Responsibilities: design and perform in vitro/ex vivo studies to investigate disease mechanisms, validate therapeutic targets, analyze complex datasets integrating genetics, clinical, and multi-omic information, and develop innovative experimental approaches. Collaborate with multidisciplinary teams, communicate findings, and foster scientific rigor and operational excellence. Qualifications: PhD or equivalent with expertise in fibroblast biology, tissue remodeling, fibrosis, or inflammation; experience with primary human cells, advanced in vitro/ex vivo models, multi-omics, and data analysis; strong communication skills and ability to work collaboratively. Preferred: experience in complex disease mechanisms, multi-disciplinary data integration, and computational approaches. High-Value: focus on autoimmune and rare diseases with immuno-inflammatory components, leveraging cutting-edge technologies, contributing to translational insights, and supporting target validation for rare diseases such as Thyroid Eye Disease. Work setup and travel are not specified.