Scientist, Oligonucleotide Synthesis
GSK
August 30, 2026
On-site
Cambridge, MA
Operations
Position Summary
- Help establish pre-clinical capabilities within GSK’s growing oligonucleotide synthesis lab, focused on SPOS of ASOs, siRNA, SSO, RNA editors screening, high-throughput automation, conjugates, and method development.
Role Responsibilities:
- Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis of ASOs, siRNA, SSO, and RNA editors with routine and novel next-generation amidite chemistries.
- Perform hands-on work and maintain high-throughput automation workflows for routine and next-generation chemistry and oligo method development.
- Maintain SOPs for synthesis, processing, and purification to ensure high-quality, reproducible results.
- Collaborate with oligo analytical and delivery chemistry teams to ensure excellence in oligonucleotide and conjugate synthesis.
- Collaborate with various teams to achieve synthetic project goals.
Required Qualifications / Skills:
- MS (2+ years) or BS (4+ years) in chemistry, chemical biology, or related field.
- Direct experience with lab automation platforms (e.g., Dynamic Devices Lynx, Tecan Fluent or similar).
- Familiarity with Mermade 192X, Dr. Oligo 192 XLc, or other high-throughput synthesizers; LC/HRMS, UPHLC, LC/MS analytics.
- Proficiency in oligonucleotide synthesis (SPOS) and understanding of RNA therapeutics (ASO, siRNA, SSO, RNA editors).
Preferred Qualifications / Skills:
- MS (2+ years) or more in oligonucleotide synthesis and/or chemistry (or related).
- Team-focused; strong initiative; ability to troubleshoot and implement new solutions.
- Excellent written/verbal communication, attention to detail, organizational skills, and collaboration.
- Conjugation chemistry experience desirable.
- Sense of urgency, flexibility, independence, accountability; strong integrity; ability to manage multiple priorities.
Working Arrangement:
- On-site role based in Cambridge, MA laboratory; hybrid/remote not available.
Application Instructions:
- Apply and tell GSK about your lab experience and contributions you want to make.
- Help establish pre-clinical capabilities within GSK’s growing oligonucleotide synthesis lab, focused on SPOS of ASOs, siRNA, SSO, RNA editors screening, high-throughput automation, conjugates, and method development.
Role Responsibilities:
- Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis of ASOs, siRNA, SSO, and RNA editors with routine and novel next-generation amidite chemistries.
- Perform hands-on work and maintain high-throughput automation workflows for routine and next-generation chemistry and oligo method development.
- Maintain SOPs for synthesis, processing, and purification to ensure high-quality, reproducible results.
- Collaborate with oligo analytical and delivery chemistry teams to ensure excellence in oligonucleotide and conjugate synthesis.
- Collaborate with various teams to achieve synthetic project goals.
Required Qualifications / Skills:
- MS (2+ years) or BS (4+ years) in chemistry, chemical biology, or related field.
- Direct experience with lab automation platforms (e.g., Dynamic Devices Lynx, Tecan Fluent or similar).
- Familiarity with Mermade 192X, Dr. Oligo 192 XLc, or other high-throughput synthesizers; LC/HRMS, UPHLC, LC/MS analytics.
- Proficiency in oligonucleotide synthesis (SPOS) and understanding of RNA therapeutics (ASO, siRNA, SSO, RNA editors).
Preferred Qualifications / Skills:
- MS (2+ years) or more in oligonucleotide synthesis and/or chemistry (or related).
- Team-focused; strong initiative; ability to troubleshoot and implement new solutions.
- Excellent written/verbal communication, attention to detail, organizational skills, and collaboration.
- Conjugation chemistry experience desirable.
- Sense of urgency, flexibility, independence, accountability; strong integrity; ability to manage multiple priorities.
Working Arrangement:
- On-site role based in Cambridge, MA laboratory; hybrid/remote not available.
Application Instructions:
- Apply and tell GSK about your lab experience and contributions you want to make.