Scientist II, ASO Process Development and Manufacturing

Role Summary

We are looking for a highly motivated and creative Scientist II to join our Oligonucleotide Chemical Development team. This role offers an exciting opportunity to contribute to the development of robust processes for synthesizing oligonucleotides. As part of this team, you will gain hands-on experience in designing and developing manufacturing processes for clinical and commercial therapeutics. You will play a pivotal role in optimizing synthesis processes, focusing on enhancing process robustness, productivity, and impurity control.

Responsibilities

• Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize and/or characterize the synthesis processes of oligonucleotides with an emphasis on improvement in process robustness and productivity and control of impurities.
• Perform pilot-scale syntheses to produce oligonucleotide compounds for purification process development and/or preclinical studies.
• Record the experimental procedures and data accurately.
• Communicate research results effectively by writing research reports and presenting data in team meetings.
• Engage in the CMC activities including authoring CMC section of INDs.
• Manage the Contract Research Organization (CRO)
• Initiate innovative research projects to improve synthesis processes.

Qualifications

• Required: Specialization in synthetic organic chemistry with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms.
• Required: Ph.D. with 0-3 years of relevant postdoc experience.
• Required: M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings.
• Required: BS with 6+ years of relevant experience in pharmaceutical or biotech settings
• Required: Ability to perform synthetic process research and development of drug candidates including conjugates and starting materials beyond platform oligonucleotides by using information from literature, conferences, seminars etc.
• Required: Knowledge in patent applications and manuscripts for publications.
• Required: Ability to work independently and collaboratively within a team environment.
• Required: Effective communication skills in both written and oral forms.

• Preferred: Experience in nucleoside chemistry or oligonucleotide synthesis
• Preferred: Experience in API synthesis process development