Scientist I, Formulation

Role Summary

We are seeking a highly motivated and detail-oriented Formulation Scientist to join our Early Development team focused on oligonucleotide-based therapeutics. The role supports design and development of drug formulations at preclinical and early clinical stages, collaborates with cross-functional teams on formulation screening, in vitro and in vivo formulation preparation, and process development for novel oligonucleotide candidates. This position reports to the Senior Principal Scientist, Formulation Lead and is based in Bedford, MA (lab-based).

Responsibilities

• Design and execute formulation studies for oligonucleotide drug products
• Prepare prototype formulations and conduct pre-formulation characterization (e.g., solubility, pH stability, buffer selection)
• Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
• Support analytical testing and interpretation of data related to physical and chemical stability
• Maintain accurate and timely documentation of experiments, protocols, and results in electronic lab notebooks
• Contribute to the preparation of technical reports, presentations, and regulatory documentation
• Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
• Additional duties as assigned

Qualifications

• PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field, Master’s degree with 6+ years of experience in formulation development, or Bachelor’s with 10+ years of experience
• Experience with nucleic acid-based therapeutics preferred
• Familiarity with oligonucleotide properties, degradation pathways, and formulation challenges
• Hands-on experience with lab techniques such as pH adjustment, UV spectroscopy, endotoxin and physical property measurement; hands-on experience with HPLC/UPLC is a plus
• Strong organizational skills and attention to detail
• Excellent communication and teamwork abilities

Additional Requirements

• Travel: Approximately 5% travel