Scientist, High Throughput Antibody Production
AstraZeneca
Full-time
On-site
Waltham, MA
Operations
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Role Summary
Scientist, High Throughput Antibody Production at AstraZeneca in Waltham, MA. Responsible for executing high-throughput antibody production and purification SOPs, delivering microgram-to-milligram quantities of antibody therapeutics, managing production campaigns, and compiling data packages for project teams.
Responsibilities
- Execute well-validated SOPs for high-throughput antibody production and purification.
- Deliver microgram-to-milligram quantities of antibody therapeutics efficiently and reliably.
- Manage scheduled production campaigns and ensure instrumentation readiness.
- Perform routine QC and compile comprehensive data packages for project teams.
- Plan production runs, manage consumables, and meet deadlines in a fast-paced environment.
Qualifications
- Required: Master’s degree with 1+ years of experience in antibody expression/purification, UPLC, or molecular biology; or Bachelor’s degree with 3+ years of experience in antibody expression/purification, UPLC, or molecular biology.
- Required: Demonstrated experience executing standardized high-throughput expression and purification workflows for antibodies or antibody-like proteins at microgram-to-milligram scale.
- Required: Hands-on operation of liquid handlers (Hamilton or Lynx preferred) using validated methods with integrated automation platforms (Biosero/Green Button Go) a plus.
- Required: Proficiency in mammalian cell culture (CHO and HEK293), aseptic technique, and transient expression.
- Required: Experience with sample tracking and laboratory logistics/LIMS software; comfort with barcode-driven workflows.
- Required: Strong attention to detail, documentation rigor, and adherence to SOPs and QC acceptance criteria.
- Required: Effective communication and collaboration across cross-functional teams.
- Preferred: Working knowledge of protein purification technologies and common analytical methods (e.g., SEC-UPLC, LC-MS, SDS-PAGE, CE).
- Preferred: Familiarity with lab automation scheduling software; Green Button Go preferred.
- Preferred: Basic scripting for data handling (e.g., Python, Jupyter).
- Preferred: Exposure to imaging or flow cytometry platforms and analysis tools (iQue, Attune, FlowJo).
Skills
- High-throughput antibody production and purification
- Cell culture (CHO, HEK293), aseptic technique
- Automation platforms and workflow scheduling
- Data handling and record-keeping
- Cross-functional collaboration
- Analytical methods (LC-MS, SEC-UPLC, SDS-PAGE, CE) – desirable
Education
- Master’s degree with relevant experience or Bachelor’s degree with relevant experience in antibody expression/purification, UPLC, or molecular biology