Scientist--ADC Biology (Non-PhD)

Role Summary

As a Scientist on our Antibody-Drug Conjugate (ADC) Biology team, you will drive the development of next-generation ADCs for cancer therapy. You will design and implement robust biological assays, identify cancer indications susceptible to payloads, and optimize pairing with tumor-associated antigens to enhance efficacy. You will analyze data and communicate findings to cross-functional teams, and you may contribute to IND- and BLA-enabling data packages to support regulatory submissions. Location: On Premise.

Responsibilities

• Apply cellular, proteomic, and molecular biology laboratory techniques to preclinical research projects in the area of cancer biology
• Execute molecular and cell-based methodologies including flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, alpha-LISA, western blotting, WES and in vitro PD assays
• Investigate novel antibody drug conjugate (ADC) targets, linker payloads, and new MOAs of our therapeutics through development, optimization, and execution of complex assays
• Independently design, execute, analyze and document key experiments to enable clear go/no-go decisions; present findings to large and small audiences
• Provide leadership within technical area of expertise; may train others
• Maintain rigorous records of experimental progress using electronic laboratory notebooks

Qualifications

• Required: Bachelor's Degree in Biology, Biochemistry, Engineering, Immunology or a related field; 6+ years of relevant industry ADC Biology or small molecule experience
• Required: Master's degree in Biology, Biochemistry, Engineering, Immunology or a related field; 4+ years of relevant industry ADC Biology or small molecule experience
• Required: Experience with tissue culture and diverse molecular biology techniques
• Required: Experience with protein quantification methods, e.g., WES, western blotting
• Required: Proficiency in flow cytometry analysis
• Required: Experience working in and adapting to a rapidly evolving environment
• Required: Experience working independently and as part of a team
• Required: Experience leveraging critical thinking to address challenges and overcome obstacles
• Required: Strong written and verbal communication skills including experience communicating effectively to a wide range of audiences
• Required: Excellent organization and planning skills
• Preferred: Knowledge of therapeutic antibodies, protein degraders, and/or ADCs
• Preferred: Knowledge of epigenetics, signal transduction, and/or metastasis pathways
• Preferred: Experience with cell-based assay development for screening purposes
• Preferred: Experience with immunohistochemistry, immunofluorescence, and/or imaging
• Preferred: Experience with utilization and analysis of data from ‘omics platforms
• Preferred: Proficiency with appropriate software for data analysis

Additional Requirements

• Physical and mental requirements: Lifting, sitting, standing, walking, bending; ability to perform mathematical calculations and to perform complex data analysis
• Travel and schedule: Occasional need to work non-standard hours; occasional travel (1–2 times per year). Must adhere to safe work practices and procedures