Scientist 1, Chemistry

Role Summary

The Scientist 1 will contribute to Crinetics’ growing drug discovery projects within the Chemistry team, responsible for the design and synthesis of small-molecule drug candidates and analyzing diverse data sets to drive Crinetics’s medicinal chemistry strategy. This onsite role is based in San Diego, CA.

Responsibilities

• Independently design, plan and execute synthesis, purification and submission of small molecule drug candidates and other molecules
• Troubleshoot chemistry problems independently
• Generate effective hypotheses to pursue, followed by experimental planning and execution
• Prepare and organize data for presentations and be able to present written and oral reports to within the team and cross-functionally
• Participate in group discussion to exchange ideas among peers
• Prioritize chemistry efforts to ensure efficient and timely progression of projects to meet company goals
• Conduct and coordinate lab tasking and responsibilities to ensure a smooth and safe operation
• Stay current in both synthetic organic and medicinal chemistry literature to support company research objectives

Qualifications

• Ph.D. in synthetic organic chemistry
• Highly skilled in methodology development and multistep synthesis with demonstration of excellent problem-solving skills
• Strong track record of achievement in synthesis of complex molecules with state-of-the-art knowledge of modern synthetic methodologies and analytical and purification techniques
• Proven track record of creative thinking and consistent delivery as demonstrated by publication/presentation/patent record
• Excellent written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, ability to interact within a multidisciplinary team
• Responds well to scientific challenges and applies significant rigor to their own work
• Proficient in using chemistry related software and database such as ChemDraw, SciFinder, Reaxys
• Laboratory experience with: Flash column systems, NMR spectroscopy, thin layer chromatography, handling pyrophoric materials, LC/MS

Skills

• Software and data tools: ChemDraw, SciFinder, Reaxys; electronic notebooks; NMR analysis
• Laboratory techniques: Flash chromatography, NMR spectroscopy, TLC, LC/MS
• Office software: Windows, MS Office (Outlook, Word, PowerPoint, Excel)

Education

• Ph.D. in synthetic organic chemistry

Additional Requirements

• Travel: Up to 5% of time
• Physical Demands: Sit for long periods; occasional walking; lifting up to 25 lbs; laboratory environment with safety requirements