R&D Manager Leadership Development Program
Legend Biotech
July 02, 2026
Remote friendly (Philadelphia, PA)
United States
Human Resources
Scientist, R&D Leadership Development Program (Philadelphia, PA)
Role Overview
Early-career rotational leadership program (3–5 years) with executive mentorship and business impact across scientific/operational/corporate functions. Focus: in-vivo CAR.
Key Responsibilities
- Lead, design, and optimize research for next-generation in-vivo CAR-T.
- Use published literature to identify novel solutions to in-vivo cell therapy challenges.
- Isolate immune cells from leukopak or blood of healthy donors/patients and evaluate in-vivo CAR virus using in-vitro assays and in-vivo mouse models.
- Conduct solid tumor research using cell biology techniques (cell culture, transfection, FACS, cell-based functional assays).
- Package/titer engineered viruses; characterize particles (protein and PCR assays); measure transduction (flow and VCN).
- Generate, manage, evaluate, and maintain critical data (e.g., ELN).
- Deliver results via internal presentations.
Requirements
- Recent PhD in Immunology or related life sciences (within last 5 years).
- 3–4 years cell/gene therapy experience; in-vivo CAR-T preferred.
- Extensive immune cell analytics/assay development (multi-parameter flow cytometry; immunogenicity assays including cytotoxicity; cytokine release ELISA/MSD multiplex).
- Lentivirus characterization/quantification (VCN and flow assays).
- Solid tumor models and in-vivo cell-specific gene delivery (plus).
- Independent project planning/execution; deep immunology/immunotherapy knowledge.
- Proficient with advanced gene delivery methods (LVV, VLP, LNP); strong lentivirus production/titering/transduction.
- Strong multitasking, problem-solving, and collaboration.
Benefits (per job posting)
Medical/dental/vision, 401(k) with match, 8 weeks paid parental leave (after 3 months), paid time off (vacation/personal/sick/holidays). Performance bonus/equity for eligible roles.
Role Overview
Early-career rotational leadership program (3–5 years) with executive mentorship and business impact across scientific/operational/corporate functions. Focus: in-vivo CAR.
Key Responsibilities
- Lead, design, and optimize research for next-generation in-vivo CAR-T.
- Use published literature to identify novel solutions to in-vivo cell therapy challenges.
- Isolate immune cells from leukopak or blood of healthy donors/patients and evaluate in-vivo CAR virus using in-vitro assays and in-vivo mouse models.
- Conduct solid tumor research using cell biology techniques (cell culture, transfection, FACS, cell-based functional assays).
- Package/titer engineered viruses; characterize particles (protein and PCR assays); measure transduction (flow and VCN).
- Generate, manage, evaluate, and maintain critical data (e.g., ELN).
- Deliver results via internal presentations.
Requirements
- Recent PhD in Immunology or related life sciences (within last 5 years).
- 3–4 years cell/gene therapy experience; in-vivo CAR-T preferred.
- Extensive immune cell analytics/assay development (multi-parameter flow cytometry; immunogenicity assays including cytotoxicity; cytokine release ELISA/MSD multiplex).
- Lentivirus characterization/quantification (VCN and flow assays).
- Solid tumor models and in-vivo cell-specific gene delivery (plus).
- Independent project planning/execution; deep immunology/immunotherapy knowledge.
- Proficient with advanced gene delivery methods (LVV, VLP, LNP); strong lentivirus production/titering/transduction.
- Strong multitasking, problem-solving, and collaboration.
Benefits (per job posting)
Medical/dental/vision, 401(k) with match, 8 weeks paid parental leave (after 3 months), paid time off (vacation/personal/sick/holidays). Performance bonus/equity for eligible roles.