Process Development Engineer IV, Upstream
Takeda
June 26, 2026
On-site
Lexington, MA
$103,500 - $162,690 USD yearly
Operations
About The Role
The Process Development Engineer IV supports upstream cell culture development for early- and late-stage biotherapeutics programs. Design and execute studies, generate and interpret data, and advance processes using bench-top bioreactors, Ambr microscale bioreactors, shake flasks, WAVE bioreactors, and high-throughput purification systems. Work cross-functionally with upstream, downstream, and analytical teams; contribute to technical documentation and use process control systems such as DeltaV. Explore emerging tools including AI and in silico approaches to improve development speed and efficiency.
How you will contribute
- Design and execute upstream development studies
- Operate and troubleshoot cell culture systems (bioreactors, Ambr, shake flasks, WAVE, high-throughput purification)
- Use DeltaV or similar control systems for process execution and data collection
- Maintain electronic laboratory notebook documentation
- Analyze data, interpret results, and summarize findings
- Prepare technical reports and study summaries
- Learn/apply AI and in silico tools
What you bring to Takeda
- BS with 5+ years, or MS with 3+ years in biochemical/chemical engineering, biotechnology, biology, or related field
- Experience in biotherapeutics upstream process development
- Hands-on upstream unit operations
- Working knowledge of DeltaV (or similar)
- Experience with electronic laboratory notebooks
- Strong data analysis and technical writing skills
- Solid understanding of upstream cell culture process development
- Ability to learn/apply new tools (incl. AI/in silico)
- Attention to detail; ability to work independently and collaboratively
Compensation and Benefits (summary)
- Lexington, MA; U.S. base salary range: $103,500–$162,690
- May be eligible for incentives and benefits (medical/dental/vision, 401(k) match, disability, life insurance, tuition reimbursement, paid time off, holidays, well-being benefits, sick time, vacation)
Application instructions
- By clicking “Apply,” acknowledge that the employment application process will commence and that submitted information will be processed per Takeda’s Privacy Notice and Terms of Use.
The Process Development Engineer IV supports upstream cell culture development for early- and late-stage biotherapeutics programs. Design and execute studies, generate and interpret data, and advance processes using bench-top bioreactors, Ambr microscale bioreactors, shake flasks, WAVE bioreactors, and high-throughput purification systems. Work cross-functionally with upstream, downstream, and analytical teams; contribute to technical documentation and use process control systems such as DeltaV. Explore emerging tools including AI and in silico approaches to improve development speed and efficiency.
How you will contribute
- Design and execute upstream development studies
- Operate and troubleshoot cell culture systems (bioreactors, Ambr, shake flasks, WAVE, high-throughput purification)
- Use DeltaV or similar control systems for process execution and data collection
- Maintain electronic laboratory notebook documentation
- Analyze data, interpret results, and summarize findings
- Prepare technical reports and study summaries
- Learn/apply AI and in silico tools
What you bring to Takeda
- BS with 5+ years, or MS with 3+ years in biochemical/chemical engineering, biotechnology, biology, or related field
- Experience in biotherapeutics upstream process development
- Hands-on upstream unit operations
- Working knowledge of DeltaV (or similar)
- Experience with electronic laboratory notebooks
- Strong data analysis and technical writing skills
- Solid understanding of upstream cell culture process development
- Ability to learn/apply new tools (incl. AI/in silico)
- Attention to detail; ability to work independently and collaboratively
Compensation and Benefits (summary)
- Lexington, MA; U.S. base salary range: $103,500–$162,690
- May be eligible for incentives and benefits (medical/dental/vision, 401(k) match, disability, life insurance, tuition reimbursement, paid time off, holidays, well-being benefits, sick time, vacation)
Application instructions
- By clicking “Apply,” acknowledge that the employment application process will commence and that submitted information will be processed per Takeda’s Privacy Notice and Terms of Use.