The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech, a member of the Roche Group.

The Opportunity

At Prescient Design, part of Genentech, we are at the forefront of transforming drug discovery through Artificial Intelligence and Machine Learning. We are building the Lab-in-the-Loop, Genentech’s cutting-edge AI platform for therapeutic molecular design. (https://www.youtube.com/watch?v=cN1PxxQWoEc). This platform is central to accelerating the discovery of new medicines by integrating massive quantities of experimental data to train predictive AI models. We seek an exceptional Principal Software Engineer to take a leading technical role in shaping the design, development, and future direction of this critical platform, enabling AI-driven drug design across Roche. We are seeking a technical leader with deep full-stack expertise, particularly skilled in building intuitive front-end experiences and scalable backend systems. The ideal candidate possesses strong product intuition, a keen eye for user experience, and proven experience in shaping technical roadmaps and designing robust service architectures for complex platforms. You thrive on technical ownership and guiding the evolution of a product from concept to production, influencing its capabilities and impact.

You will collaborate closely with Prescient's AI scientists and engineers, Genentech Computational Sciences (gCS) colleagues, including machine learning specialists, Genentech Research & Early Development (gRED) Drug Discovery teams like Antibody Engineering, and other teams across the Roche group. Your role will be key in identifying, strategizing, and productionalizing high-impact AI applications across the drug discovery pipeline. Prescient Design offers a dynamic environment for cutting-edge, multidisciplinary research in AI and drug discovery, providing access to rich data sources, close links to top academic institutions, and internal Genentech and Roche partners.

In this role, you will:

• Contribute to the strategic roadmap for the Prescient "Lab-in-the-Loop" platform, guiding product features and technical architecture to maximize AI impact in drug discovery.
• Take a leading role in the full-stack design and development of scalable, reliable software systems, including crafting responsive and intuitive front-end applications that form the core of our AI/ML platform.
• Collaborate closely with Machine Learning Scientists, AI Engineers, and experimental specialists, translating complex scientific workflows into intuitive user interfaces, dashboards, and analytics tools with a strong focus on user experience.
• Explore and implement integrations with novel AI agents and models to enhance platform capabilities and automate complex tasks.
• Mentor and provide technical guidance to other software engineers on the team, fostering best practices and high-quality engineering.

Who You Are

• 10 + years of software engineering work experience, delivering complex, full-stack applications.
• Proven expertise in front-end development using modern frameworks (e.g., React, Angular) and building intuitive, user-centered interfaces.
• Intense curiosity about the biology of disease and eagerness to contribute to scientific and computational efforts.
• Proficiency with Python and SQL.

Preferred

• Familiarity with ML concepts or frameworks (e.g., PyTorch).
• Domain experience in drug discovery, computational biology, bioinformatics, and cheminformatics.

Relocation and Salary

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of New York is $145,100 - 269,500 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.