Principal Scientist, Functional Genomics

Role Summary

Principal Scientist, Functional Genomics, based in Cambridge, MA. The role drives the implementation and application of emerging functional genomics approaches (such as Perturb-seq) to elucidate disease mechanisms and discover novel targets across immunology, ophthalmology, neurology, oncology, and rare disease. Collaboration with computational colleagues will advance a lab-in-a-loop approach integrating AI with functional genomics to accelerate therapeutic target discovery.

Responsibilities

• Design and execute high-throughput, multi-modal functional genomics experiments such as Perturb-seq, including cell culture and genetic perturbation.
• Innovate in functional genomics technology by refining experimental methodologies to systematically explore gene function in disease contexts.
• Collaborate closely with therapeutic area and computational biology experts to advance therapeutic discovery and the application of AI to functional genomics in a ‘lab-in-a-loop’.
• Communicate your work through scientific publications, patent and regulatory filings, and presentations at internal and external meetings.
• Support the personal and technical development of junior staff members.

Qualifications

• Ph.D. in genomics, molecular biology, cell biology, systems biology, or related field
• 5 years post-doctoral training and/or equivalent industry experience
• Experience applying cutting-edge functional genomics tools to target or drug discovery, especially in immunology, ophthalmology, or neurology

Skills

• Hands-on experience in disease modeling in primary cells, iPSC-derived cells, and/or organoids
• Experience in high-throughput assay development, screening platforms and robotics, flow cytometry, imaging, single cell or spatial genomics, and/or computational data analysis
• Excellent communication, organizational, and team skills with a track record of success working collaboratively across disciplines