Principal Scientist/Associate Director, Biology

Role Summary

Principal Scientist/Associate Director, Biology will join Disc Medicine's Innovation team and report to the Senior Director, Biology & Innovation Research. The role leads discovery projects for biologics, designs and oversees in vitro and in vivo studies to advance the discovery pipeline, and communicates project updates to cross-functional teams. The incumbent will contribute across projects at various discovery and development stages with opportunities for professional development. This is a hybrid role with remote work flexibility and headquarters in Watertown, MA.

Responsibilities

• Provide scientific leadership in the planning, execution, and interpretation of data across multiple biologics discovery programs.
• Critically evaluate scientific literature, synthesize novel hypotheses and design rigorous experimental strategies to test them.
• Drive the development and characterization of animal models to support research across diverse disease indications.
• Design and oversee in vivo pharmacology studies to assess PK/PD, efficacy, and mechanism of action of drug candidates.
• Support the identification, characterization, and selection of lead molecules to advance pipeline programs.
• Collaborate in the evaluation and selection of external partners to support in vitro and in vivo research activities.
• Communicate project progress and key findings effectively in cross-functional meetings, ensuring alignment with timelines in a fast-paced, dynamic environment.
• Foster a collaborative and accountable team culture, with a strong emphasis on scientific excellence and continuous improvement.

Qualifications

• Ph.D. in Biology, Biomedical Sciences, or a related field.
• 10 -12 years of related work experience with at least 5 years of experience working within the biotechnology or pharmaceutical research industry.
• Extensive experience in biologics discovery, including fusion proteins and multispecific antibodies.
• Strong background in developing and characterizing in vitro, ex vivo, and in vivo models, with deep knowledge of disease biology, pathogenesis, and mechanisms of action.
• Demonstrated ability to think critically and independently, propose innovative scientific approaches, and apply strong analytical and problem-solving skills to complex biological questions.
• Hands-on expertise in in vivo animal studies.
• Experience working with contract research organizations (CROs) is preferred.
• Outstanding communication skills—both written and verbal—with the ability to thrive within a collaborative work environment.