Principal Scientist, Analytical Development
Bristol Myers Squibb
June 25, 2026
Remote friendly (Cambridge, MA)
United States
Operations
Position Summary:
Senior or Principal Scientist (Analytical Development) to advance analytical methods supporting development and manufacturing of RNA therapeutics, using chromatography and mass spectrometry for assays characterizing RNA drug substance and lipid nanoparticle (LNP) drug products.
Responsibilities:
- Serve as subject matter expert in separation science; develop novel analytical methods for RNA-based products and delivery systems.
- Investigate new techniques/technologies to support R&D across product development stages.
- Establish methods to identify/characterize LNP-related impurities and assess critical quality attributes of protein-conjugated LNPs.
- Transfer methods to internal/external testing labs; provide SOPs, technical reports, and method qualification plans for verification/qualification/validation.
- Collaborate with RNA Process Development, LNP PD, research, and preclinical manufacturing to meet timelines and testing needs.
- Lead troubleshooting; supervise analytical testing and review data.
- Operate/maintain HPLC and mass spectrometry.
- Document and communicate results; apply creativity to build an analytical platform.
Qualifications:
- Ph.D. in Analytical Chemistry, Biochemistry, or related field with 8+ years CMC experience (B.S./M.S. with relevant experience considered).
- Extensive chromatography (HPLC/UPLC) experience across separation modes: reversed phase, ion exchange, size exclusion, AFF4F; MS/MALS/CAD detection proficiency.
- Hands-on LNP impurity characterization and method development desired.
- Strongly preferred: RNA/oligonucleotides, lipid nanoparticles, and/or proteomics.
- Preferred: GxP principles; advantageous: early-stage product development.
- Strong problem-solving, teamwork, independence, and attention to detail.
Compensation/Benefits:
- Cambridge, MA, US: $137,810–$166,994.
- Health coverage; wellbeing support; 401(k) and insurance/protection benefits; paid time off (details by employee/location).
Application instruction:
- If intrigued but not a perfect resume match, you are encouraged to apply anyway.
Senior or Principal Scientist (Analytical Development) to advance analytical methods supporting development and manufacturing of RNA therapeutics, using chromatography and mass spectrometry for assays characterizing RNA drug substance and lipid nanoparticle (LNP) drug products.
Responsibilities:
- Serve as subject matter expert in separation science; develop novel analytical methods for RNA-based products and delivery systems.
- Investigate new techniques/technologies to support R&D across product development stages.
- Establish methods to identify/characterize LNP-related impurities and assess critical quality attributes of protein-conjugated LNPs.
- Transfer methods to internal/external testing labs; provide SOPs, technical reports, and method qualification plans for verification/qualification/validation.
- Collaborate with RNA Process Development, LNP PD, research, and preclinical manufacturing to meet timelines and testing needs.
- Lead troubleshooting; supervise analytical testing and review data.
- Operate/maintain HPLC and mass spectrometry.
- Document and communicate results; apply creativity to build an analytical platform.
Qualifications:
- Ph.D. in Analytical Chemistry, Biochemistry, or related field with 8+ years CMC experience (B.S./M.S. with relevant experience considered).
- Extensive chromatography (HPLC/UPLC) experience across separation modes: reversed phase, ion exchange, size exclusion, AFF4F; MS/MALS/CAD detection proficiency.
- Hands-on LNP impurity characterization and method development desired.
- Strongly preferred: RNA/oligonucleotides, lipid nanoparticles, and/or proteomics.
- Preferred: GxP principles; advantageous: early-stage product development.
- Strong problem-solving, teamwork, independence, and attention to detail.
Compensation/Benefits:
- Cambridge, MA, US: $137,810–$166,994.
- Health coverage; wellbeing support; 401(k) and insurance/protection benefits; paid time off (details by employee/location).
Application instruction:
- If intrigued but not a perfect resume match, you are encouraged to apply anyway.