Principal Research Scientist I, Process Chemistry (Biocatalysis)

Role: Principal Research Scientist I focusing on chemical process research and development of small molecules, peptides, antibody-drug conjugates, and other modalities via biocatalysis. Responsibilities: develop biocatalytic processes for API synthesis, engineer enzymes through recombinant DNA, directed evolution, and bioinformatics; integrate AI/ML and high-throughput experimentation to optimize reactions; contribute to process development, characterization, and regulatory documentation; author scientific publications and present findings. Qualifications: PhD in organic chemistry or related field with 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of experience; expertise in synthetic organic chemistry, biocatalysis, enzyme screening, protein expression, and data analysis; proficiency with AI/ML tools and automation technologies; demonstrated leadership and collaboration skills; experience with process development in biopharma context. HighValue: small molecule APIs, biocatalysis, enzyme engineering, AI/ML applications, GxP compliance, process development, cross-functional team collaboration. WorkSetup: not specified.