Principal Research Scientist I

Role Summary

The Genomics Research Center at AbbVie is seeking a talented and motivated Principal Research Scientist to support immunology clinical trials, pharmacogenetics and reverse translation efforts. This role focuses on understanding the biology of autoimmune diseases and delivering genomic analyses to inform the Immunology pipeline.

Responsibilities

• Provide scientific leadership and genomic expertise to immunology clinical trials, integrating genetics, transcriptomics, and other molecular data into trial design and analysis.
• Design and execute strategy and interpret clinical and real-world data to derive mechanistic insights from clinical samples.
• Collaborate closely with discovery, clinical, biomarker, bioinformatics, and translational medicine teams to inform decision-making and study objectives.
• Interpret complex multi-omics datasets, integrating clinical outcomes with molecular profiles.
• Communicate findings clearly to both scientific and cross-functional audiences through presentations, reports, and publications.
• Stay abreast of emerging scientific trends and technologies relevant to immunology and genomics, recommending their adoption when appropriate.
• Build external scientific connections which foster professional development and promote the reputation of the Genomics Research Center.

Qualifications

• Required: BS or equivalent with typically 14+ years of experience; MS or equivalent with typically 12+ years; PhD with typically 6+ years in a relevant scientific area.
• Demonstrated experience (5+ years) supporting clinical or translational research in immunology or related therapeutic areas, preferably in an industry setting.
• Expertise in interpreting high-dimensional genomics data (genetics, transcriptomics, single-cell, etc.).
• Familiarity with omics databases and biobanks.
• Experience working with clinical trial design, biomarkers, or reverse translation strongly preferred.
• Excellent problem-solving, project management, and communication skills.
• Ability to work collaboratively in a multidisciplinary, fast-paced environment.

• Preferred: PhD, MD/PhD, or equivalent in Genetics, Molecular Biology, Immunology or a related field.
• Previous industry experience in pharmaceutical or biotechnology companies.
• Experience in supporting target progression across discovery and development pipeline.
• Track record of scientific publications and presentations.