Principal Research Scientist I (Analytical R&D for LNP and Small Molecule)
AbbVie
July 02, 2026
Remote friendly (Worcester, MA)
United States
$124,500 - $236,500 USD yearly
Other
Responsibilities:
- Apply analytical separation and detection methods for complex impurity profiling of pharmaceutical products to advise molecule selection.
- Generate new scientific proposals and lead efforts; anticipate and respond to scientific/regulatory advances or competitive threats.
- Demonstrate scientific initiative and creativity; maintain high lab productivity.
- Embrace others’ ideas, nurture and manage innovation to reality.
- Raise the bar; drive continuous improvement.
- Understand and comply with safety, quality, and regulatory policies and government regulations.
Qualifications:
- Bachelors, Masters, or Ph.D. in Analytical Chemistry with typically 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
- Strong analytical chemistry background; excellent analytical problem-solving; independently develop and troubleshoot analytical methods.
- Leadership in solving technical challenges across therapeutic modalities, specifically lipid nanoparticles (LNP) and small molecules.
- Highly desired: demonstrated experience with mass spectrometry (MS) instrumentation for structure elucidation and trace quantitation.
- Working knowledge of HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
- Familiarity with physicochemical properties in drug delivery/formulation design.
- Working knowledge of formulation approaches and routes of administration (IV, SC, IP, PO) across multiple species.
- Knowledge of preclinical/clinical formulation development principles for lipid nanoparticles.
- Creative out-of-the-box problem solving; self-motivated, detail-oriented; able to work in fast-paced teams.
- High-quality written/oral communication; interact effectively with interdisciplinary scientists/engineers.
Work Location:
- AbbVie Bioresearch Center (Worcester, MA) with 50% on-site support there and 50% on-site support at AbbVie Cambridge Crossing (Cambridge, MA) based on project needs.
- Apply analytical separation and detection methods for complex impurity profiling of pharmaceutical products to advise molecule selection.
- Generate new scientific proposals and lead efforts; anticipate and respond to scientific/regulatory advances or competitive threats.
- Demonstrate scientific initiative and creativity; maintain high lab productivity.
- Embrace others’ ideas, nurture and manage innovation to reality.
- Raise the bar; drive continuous improvement.
- Understand and comply with safety, quality, and regulatory policies and government regulations.
Qualifications:
- Bachelors, Masters, or Ph.D. in Analytical Chemistry with typically 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
- Strong analytical chemistry background; excellent analytical problem-solving; independently develop and troubleshoot analytical methods.
- Leadership in solving technical challenges across therapeutic modalities, specifically lipid nanoparticles (LNP) and small molecules.
- Highly desired: demonstrated experience with mass spectrometry (MS) instrumentation for structure elucidation and trace quantitation.
- Working knowledge of HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
- Familiarity with physicochemical properties in drug delivery/formulation design.
- Working knowledge of formulation approaches and routes of administration (IV, SC, IP, PO) across multiple species.
- Knowledge of preclinical/clinical formulation development principles for lipid nanoparticles.
- Creative out-of-the-box problem solving; self-motivated, detail-oriented; able to work in fast-paced teams.
- High-quality written/oral communication; interact effectively with interdisciplinary scientists/engineers.
Work Location:
- AbbVie Bioresearch Center (Worcester, MA) with 50% on-site support there and 50% on-site support at AbbVie Cambridge Crossing (Cambridge, MA) based on project needs.