Postdoctoral Scientist – Fibrosis, Liver Disease

Role Summary

The Inflammation Biology group is seeking a passionate and driven Postdoctoral Scientist to pursue innovative research at the forefront of chronic fibrotic liver disease. This role offers a unique opportunity to explore the complex biology of conditions such as metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). The successful candidate will spearhead an independent research project focused on uncovering novel pathogenic mechanisms and identifying therapeutic targets in chronic fibrotic diseases. This is a three-year postdoctoral training position at Gilead. The role is embedded in a highly collaborative and resource-rich environment, offering access to world-class facilities and cross-functional expertise across Gilead’s research ecosystem.

Responsibilities

• The successful candidate will initiate and lead independent research projects to investigate pathogenic mechanisms in chronic fibrotic liver disease
• They will utilize Gilead’s rich single cell and spatial transcriptomic datasets as well as clinical datasets to uncover novel mechanisms driving fibrotic niche expansion
• The candidate will use a combination of mouse genetic and pharmacology approaches to investigate key disease drivers and establish novel ex vivo models allowing for target identification and screening
• With the support of a mentor, the postdoctoral scientist will design, conduct, and analyze in vitro and in vivo experiments to drive research towards publication in a top-tier journal

Qualifications

• Basic Qualifications: Ph.D. in biochemistry, molecular biology, immunology or related discipline; at least one first author paper published or accepted in a peer-reviewed journal; proficiency in mammalian cell biology and biochemistry techniques; excellent written, verbal, and interpersonal communication skills and strong organizational skills
• Preferred Qualifications: Broad hands-on expertise in cell biology, molecular biology, biochemistry and imaging techniques including in vitro cell-based functional assays, primary cell cultures, transfection/transduction techniques, CRISPR/Cas9, microscopy, flow cytometry, and other immunoassays; hands-on experience with mouse models of disease, mouse handling, in-life procedures and tissue harvesting; familiarity with analysis of large-scale multiomic datasets such as single-cell and spatial transcriptomics; experience developing complex primary cell co-culture systems; demonstrated skills in leading hypothesis-driven biological research and strong cross-functional collaboration and communication

Education

• Ph.D. in biochemistry, molecular biology, immunology or related discipline