Post-Doctoral Scientist, Bioconjugation Process Innovation
Eli Lilly and Company
June 25, 2026
On-site
Indianapolis, IN
Operations
Position Summary
Postdoctoral position in Purification Process Development (BR&D) advancing In-Process Conjugation (IPC) as a next-generation manufacturing platform for Antibody RNA Conjugates (ARC) and Antibody Drug Conjugates (ADC). Crosses downstream purification, conjugation chemistry, and process analytics.
Responsibilities
- Design and execute purification development experiments to evaluate/optimize in-process conjugation workflow.
- Collaborate with Bioconjugation on conjugation efficiency and product quality attributes.
- Collaborate with Analytical teams to assess impurity detectability.
- Work with Medicine Foundry and PAT collaborators to integrate in-line process analytics for real-time CQA monitoring.
- Collaborate with Virology to assess impacts on viral clearance.
- Rigorously document results; author technical reports; contribute to patent filings and peer-reviewed publications per IP processes.
- Present findings at internal forums every 3–6 months.
Basic Requirements
- Ph.D. in Chemical Engineering, Biochemistry, Chemistry, Biomolecular Engineering, or related field, conferred within the past 3 years (or anticipated before start).
- Hands-on preparative protein chromatography (affinity, IEX, HIC, SEC) using ÄKTA or equivalent systems.
Additional Preferences
- Antibody conjugate modalities (ADC/ARC) and/or bioconjugation chemistry.
- Analytical methods for conjugate development (LC-MS, ELISA, HCP assays, DAR determination).
- TFF/membrane separation exposure.
- Interest/experience with PAT or process intensification.
- Strong written/oral communication; publication/conference experience preferred.
- Highly collaborative; self-directed and motivated for biopharma industry career.
Additional Information
- Fixed term: 2 years (potential extension to 4 years). Potential to apply for full-time roles afterward.
- Compensation: $58,000–$123,200; may be eligible for company bonus; comprehensive benefits include 401(k), pension, vacation, medical/dental/vision/prescription coverage, flexible benefits, life insurance, time off/leave, and well-being benefits.
Postdoctoral position in Purification Process Development (BR&D) advancing In-Process Conjugation (IPC) as a next-generation manufacturing platform for Antibody RNA Conjugates (ARC) and Antibody Drug Conjugates (ADC). Crosses downstream purification, conjugation chemistry, and process analytics.
Responsibilities
- Design and execute purification development experiments to evaluate/optimize in-process conjugation workflow.
- Collaborate with Bioconjugation on conjugation efficiency and product quality attributes.
- Collaborate with Analytical teams to assess impurity detectability.
- Work with Medicine Foundry and PAT collaborators to integrate in-line process analytics for real-time CQA monitoring.
- Collaborate with Virology to assess impacts on viral clearance.
- Rigorously document results; author technical reports; contribute to patent filings and peer-reviewed publications per IP processes.
- Present findings at internal forums every 3–6 months.
Basic Requirements
- Ph.D. in Chemical Engineering, Biochemistry, Chemistry, Biomolecular Engineering, or related field, conferred within the past 3 years (or anticipated before start).
- Hands-on preparative protein chromatography (affinity, IEX, HIC, SEC) using ÄKTA or equivalent systems.
Additional Preferences
- Antibody conjugate modalities (ADC/ARC) and/or bioconjugation chemistry.
- Analytical methods for conjugate development (LC-MS, ELISA, HCP assays, DAR determination).
- TFF/membrane separation exposure.
- Interest/experience with PAT or process intensification.
- Strong written/oral communication; publication/conference experience preferred.
- Highly collaborative; self-directed and motivated for biopharma industry career.
Additional Information
- Fixed term: 2 years (potential extension to 4 years). Potential to apply for full-time roles afterward.
- Compensation: $58,000–$123,200; may be eligible for company bonus; comprehensive benefits include 401(k), pension, vacation, medical/dental/vision/prescription coverage, flexible benefits, life insurance, time off/leave, and well-being benefits.