Portfolio & Program Management Director

Role Summary

Director of Portfolio and Program Management (PPM) for Cystic Fibrosis (CF) driving strategic execution from development through commercialization. Requires deep experience in early- and late-stage clinical development and commercial launch planning. Partner with program leads and cross-functional teams to ensure alignment, accountability, and delivery of program objectives.

Responsibilities

• Partner with Program Team Leads to define cross-functional strategies and decision-making frameworks that align with program goals.
• Lead the development and execution of integrated program plans, identifying critical path activities, interdependencies, and potential bottlenecks.
• Facilitate high-impact meetings, ensuring clear communication, stakeholder alignment, and timely follow-through on decisions and action items.
• Translate complex scientific and business topics into compelling narratives and presentations for internal and external stakeholders.
• Collaborate across clinical, regulatory, manufacturing, commercial, and market access functions to ensure cohesive program execution.
• Guide the development of asset-level assumptions for long-range planning and annual budgeting.
• Proactively identify and mitigate program risks, escalating issues as needed to maintain momentum and alignment.
• Monitor and manage resource allocation, identifying synergies and resolving constraints across programs.
• Establish and reinforce team operating norms to drive high performance and continuous improvement.
• Mentor and develop junior team members, fostering growth in program management capabilities.
• Provide strategic and operational leadership for programs in late-stage clinical development, ensuring readiness for regulatory submission and approval.
• Partner with commercial and launch readiness teams to align development timelines with go-to-market strategies and ensure successful product launches.

Qualifications

• Required: Bachelor’s degree in Life Sciences or related field; advanced degree preferred.
• Required: Typically 10+ years of experience managing cross-functional drug development teams, with success in early- and late-stage clinical development and commercial launch execution.

Knowledge And Skills

• Deep expertise in project and portfolio management principles, tools, and methodologies.
• Proven leadership in managing complex, cross-functional drug development programs, including early- and late-stage clinical trials and commercial launch preparation.
• Strong business acumen with ability to assess program scenarios across financial, timeline, and resource dimensions.
• Excellent communication and storytelling skills to influence at all levels of the organization.
• Comprehensive understanding of the pharmaceutical development lifecycle from discovery through commercialization.
• Highly organized with ability to manage multiple priorities in a dynamic environment.
• Collaborative mindset with a track record of building strong partnerships across functions.

Education

• Bachelor’s degree in Life Sciences or related field required; advanced degree preferred.