Mixed Modality (Peptide Upstream) Scientist - Process Translation and Execution
Eli Lilly and Company
August 29, 2026
On-site
Indianapolis, IN
Operations
Responsibilities:
- Evaluate and facilitate transfer of peptide upstream manufacturing processes (SPPS; Cleavage & Precipitation) from development to pilot plant (kilo-scale, isolator).
- Assess synthetic routes; order/stage chemicals; obtain reference materials and set up analytical methods.
- Reprocess/analyze analytical data; execute familiarization for plant readiness.
- Perform use-tests of key raw materials; document Definitive Lab Trials.
- Maintain detailed lab notebooks; prepare technical packages for accurate replication.
- Author/review tech transfer documents (tech transfer plan, SOPs, batch records, campaign/deviation reports).
- Apply process improvement and troubleshoot deviations/non-conformances; support RCA and CAPAs.
Basic Requirements:
- B.S. or M.S. in chemistry/chemical engineering or related field.
- 3+ years peptide chemistry and/or synthetic peptide API/drug substance manufacturing experience; solid phase peptide synthesis preferred.
- Authorized to work in the U.S. full-time; Lilly does not sponsor visas.
Additional Preferences:
- Knowledge of peptide chemistry/mechanisms for optimization; synthetic/scaling experience.
- Batch record creation; scale-up experiments; analytic skills (HPLC/UPLC, LC-MS, GC, NMR); mass balance.
- Experience with downstream purification (e.g., TFF, lyophilization), precipitation, and solids handling.
- Strong data analysis, RCA problem-solving, project drive, communication, and cross-functional collaboration.
Other Information:
- Initial Indianapolis/Carmel; permanent Lebanon, IN. Travel <5%. Work in manufacturing/lab environments.
- Benefits: eligibility for 401(k), medical/dental/vision, flexible benefits, life insurance, time off/leave, and well-being programs (per plan).
- Evaluate and facilitate transfer of peptide upstream manufacturing processes (SPPS; Cleavage & Precipitation) from development to pilot plant (kilo-scale, isolator).
- Assess synthetic routes; order/stage chemicals; obtain reference materials and set up analytical methods.
- Reprocess/analyze analytical data; execute familiarization for plant readiness.
- Perform use-tests of key raw materials; document Definitive Lab Trials.
- Maintain detailed lab notebooks; prepare technical packages for accurate replication.
- Author/review tech transfer documents (tech transfer plan, SOPs, batch records, campaign/deviation reports).
- Apply process improvement and troubleshoot deviations/non-conformances; support RCA and CAPAs.
Basic Requirements:
- B.S. or M.S. in chemistry/chemical engineering or related field.
- 3+ years peptide chemistry and/or synthetic peptide API/drug substance manufacturing experience; solid phase peptide synthesis preferred.
- Authorized to work in the U.S. full-time; Lilly does not sponsor visas.
Additional Preferences:
- Knowledge of peptide chemistry/mechanisms for optimization; synthetic/scaling experience.
- Batch record creation; scale-up experiments; analytic skills (HPLC/UPLC, LC-MS, GC, NMR); mass balance.
- Experience with downstream purification (e.g., TFF, lyophilization), precipitation, and solids handling.
- Strong data analysis, RCA problem-solving, project drive, communication, and cross-functional collaboration.
Other Information:
- Initial Indianapolis/Carmel; permanent Lebanon, IN. Travel <5%. Work in manufacturing/lab environments.
- Benefits: eligibility for 401(k), medical/dental/vision, flexible benefits, life insurance, time off/leave, and well-being programs (per plan).