Manager, Site Reliability Engineer

Role: Lead and manage the Site Reliability Engineering (SRE) and site operations functions for Twist Bioscience, focusing on cloud infrastructure, platform reliability, scalability, security, and performance. Responsibilities: oversee cloud architecture and operations across AWS, Azure, or GCP; maintain high availability of critical applications; drive automation, observability, monitoring, incident management, and security compliance; manage Kubernetes environments, networking, storage, and CDN services (including Akamai); collaborate with engineering teams to optimize deployment, resilience, and performance; develop CI/CD workflows and infrastructure-as-code practices; mentor SRE engineers and foster a culture of reliability. Requirements: 5–7+ years in SRE, infrastructure, or operations roles; proven leadership or mentorship experience; strong hands-on expertise with cloud platforms (AWS, Azure, GCP); Kubernetes in production; networking fundamentals and CDN management; observability systems (e.g., Splunk); scripting/automation skills (Python, Bash, Terraform); incident troubleshooting and management skills; excellent cross-functional communication. Preferred: experience with hybrid/multi-cloud environments, GitOps, security, and highly available enterprise SaaS platforms. High-Value: cloud infrastructure, Kubernetes, observability, automation, security, incident management, hybrid/multi-cloud, infrastructure-as-code. WorkSetup: hybrid in South San Francisco; no travel specified.